Band 3/AE1 anticorps (N-Term)

N° du produit ABIN2778128

Détail du produit anti-Band 3/AE1 anticorps

Antigène: Band 3/AE1 (SLC4A1) (Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1))

Épitope: N-Term

Reactivité: Humain, Lapin, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Band 3/AE1 est non-conjugé

Application: Western Blotting (WB)

Séquence: PSQPLLPQHS SLETQLFCEQ GDGGTEGHSP SGILEKIPPD SEATLVLVGR

Homologie: Horse: 85%, Human: 100%, Rabbit: 85%

Attributs du produit: This is a rabbit polyclonal antibody against SLC4A1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human SLC4A1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 911 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Band 3/AE1

Antigène: Band 3/AE1 (SLC4A1) (Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1))

Autre désignation: SLC4A1 (SLC4A1 Produits)

Synonymes: anticorps AE1, anticorps BND3, anticorps CD233, anticorps DI, anticorps EMPB3, anticorps EPB3, anticorps FR, anticorps RTA1A, anticorps SW, anticorps WD, anticorps WD1, anticorps WR, anticorps Ae1, anticorps Empb3, anticorps l11Jus51, anticorps ae1, anticorps band3, anticorps MGC152771, anticorps zgc:111889, anticorps zgc:152771, anticorps si:dz180g5.1, anticorps LOC100136769, anticorps slc4a1, anticorps wd1, anticorps bnd3, anticorps epb3, anticorps cd233, anticorps empb3, anticorps rta1a, anticorps MGC80391, anticorps SLC4A1, anticorps BB3, anticorps EAT, anticorps solute carrier family 4 member 1 (Diego blood group), anticorps solute carrier family 4 (anion exchanger), member 1, anticorps solute carrier family 4 (anion exchanger), member 1a (Diego blood group), anticorps Band 3, anticorps erythrocyte membrane protein band 4.1 like 3, anticorps solute carrier family 4 member 1 (Diego blood group) L homeolog, anticorps solute carrier family 4 member 1, anticorps SLC4A1, anticorps Slc4a1, anticorps slc4a1a, anticorps LOC100136769, anticorps EPB41L3, anticorps slc4a1.L, anticorps slc4a1

Sujet: The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40 kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis.
Alias Symbols: DI, FR, SW, WD, WR, AE1, CHC, SAO, WD1, BND3, EPB3, SPH4, CD233, EMPB3, RTA1A
Protein Interaction Partner: UBC, PIN1, HECW2, CBX8, CBX5, MDC1, TRPM8, TXLNG, SBDS, TTC4, SUMO2, Mad2l2,
Protein Size: 911

Poids moléculaire: 102 kDa

ID gène: 6521

NCBI Accession: NM_000342, NP_000333

UniProt: P02730