XRCC6 anticorps (N-Term)

N° du produit ABIN2778270

Détail du produit anti-XRCC6 anticorps

Antigène: XRCC6 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Lapin, Chien, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp XRCC6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: NFKNIYVLQE LDNPGAKRIL ELDQFKGQQG QKRFQDMMGH GSDYSLSEVL

Homologie: Dog: 93%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against G22P1. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human G22P1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 609 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur XRCC6

Antigène: XRCC6 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6))

Autre désignation: G22P1 (XRCC6 Produits)

Synonymes: anticorps CTC75, anticorps CTCBF, anticorps G22P1, anticorps KU70, anticorps ML8, anticorps TLAA, anticorps 70kDa, anticorps G22p1, anticorps Ku70, anticorps Kup70, anticorps X-ray repair cross complementing 6, anticorps ATP-dependent DNA helicase II, 70 kDa subunit, anticorps X-ray repair complementing defective repair in Chinese hamster cells 6 L homeolog, anticorps X-ray repair complementing defective repair in Chinese hamster cells 6, anticorps XRCC6, anticorps Bm1_41430, anticorps xrcc6.L, anticorps Xrcc6

Sujet: The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.
Alias Symbols: ML8, KU70, TLAA, CTC75, CTCBF, G22P1
Protein Interaction Partner: UBC, ELF3, EHF, CHD1L, SUMO2, SUMO3, MDM2, EMD, ATRX, RPA3, RPA2, RPA1, PCNA, EED, PRPF40A, SUPT5H, ST13, SET, PLOD2, PIN1, NARS, MSH2, RPSA, JUP, IMPDH1, MSH6, GART, DPYSL3, CTNNA1, SAMHD1, ATP6V1B2, GANAB, SWAP70, WBP4, HYOU1, FARSB, RANBP3, CUL2, CSDE1
Protein Size: 609

Poids moléculaire: 70 kDa

ID gène: 2547

NCBI Accession: NM_001469, NP_001460

UniProt: Q6FG89

Pathways: Réparation de l'ADN