INSIG2 anticorps (N-Term)

N° du produit ABIN2778637

Détail du produit anti-INSIG2 anticorps

Antigène: INSIG2 (Insulin Induced Gene 2 (INSIG2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chévre, Cheval, Lapin, Chien, Porc, Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp INSIG2 est non-conjugé

Application: Western Blotting (WB)

Séquence: MAEGETESPG PKKCGPYISS VTSQSVNLMI RGVVLFFIGV FLALVLNLLQ

Homologie: Cow: 100%, Dog: 92%, Goat: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Pig: 92%, Rabbit: 100%, Rat: 92%, Sheep: 100%

Attributs du produit: This is a rabbit polyclonal antibody against INSIG2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human INSIG2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 225 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-INSIG2 (ABIN2778637)

Yu, Wang, Fok, Coles, Salmon, Pérez: "Rapamycin and dietary restriction induce metabolically distinctive changes in mouse liver." dans: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 70, Issue 4, pp. 410-20, (2015) (PubMed).

Détails sur INSIG2

Antigène: INSIG2 (Insulin Induced Gene 2 (INSIG2))

Autre désignation: INSIG2 (INSIG2 Produits)

Synonymes: anticorps MGC82156, anticorps INSIG-2, anticorps 2900053I11Rik, anticorps C730043J18Rik, anticorps Insig-2, anticorps insulin induced gene 2, anticorps insulin induced gene 2 L homeolog, anticorps insig2, anticorps insig2.L, anticorps INSIG2, anticorps Insig2

Sujet: INSIG2 is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi.The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MGC26273
Protein Interaction Partner: RNF5, HMGCR, SCAP, SREBF1, RNF139, UBQLN1, UBQLN2, FAF2, ADRM1, PSMD14, BAG6, VCP, UBC, RPN1, PSMD13, PSMD12, PSMD11, PSMD4, PSMC6, PSMC5, PSMC3, PSMC2, PSMB3, PSMB1, PSMA7, PSMA2, LGALS7, JUP, INSIG1, HSPA8, HSPA6, HSPA5, HSPA1A, ENO1, DSP, AMFR, SREBF2,
Protein Size: 225

Poids moléculaire: 25 kDa

ID gène: 51141

NCBI Accession: NM_016133, NP_057217

UniProt: Q9Y5U4

Pathways: ER-Nucleus Signaling