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TRAF6 anticorps (C-Term)

TRAF6 Reactivité: Humain, Souris, Rat, Boeuf (Vache), Porc, Lapin, Cheval WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2779328
  • Antigène Voir toutes TRAF6 Anticorps
    TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))
    Épitope
    • 15
    • 9
    • 8
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 58
    • 31
    • 25
    • 15
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat, Boeuf (Vache), Porc, Lapin, Cheval
    Hôte
    • 56
    • 5
    • 2
    Lapin
    Clonalité
    • 54
    • 9
    Polyclonal
    Conjugué
    • 40
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TRAF6 est non-conjugé
    Application
    • 59
    • 18
    • 14
    • 13
    • 13
    • 11
    • 11
    • 11
    • 7
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    FGYVTFMHLE ALRQRTFIKD DTLLVRCEVS TRFDMGSLRR EGFQPRSTDA
    Homologie
    Cow: 100%, Horse: 100%, Human: 100%, Mouse: 91%, Pig: 100%, Rabbit: 100%, Rat: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against TRAF6. It was validated on Western Blot.
    Immunogène
    The immunogen is a synthetic peptide directed towards the C-terminal region of Human TRAF6
    Top Product
    Discover our top product TRAF6 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeat freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))
    Autre désignation
    TRAF6 (TRAF6 Produits)
    Synonymes
    anticorps MGC:3310, anticorps RNF85, anticorps 2310003F17Rik, anticorps AI851288, anticorps C630032O20Rik, anticorps rnf85, anticorps traf6, anticorps xtraf6, anticorps CG10961, anticorps DTRAF2, anticorps Dmel\\CG10961, anticorps TRAF, anticorps TRAF2, anticorps TRAF6, anticorps Traf2, anticorps dTRAF2, anticorps dTRAF6, anticorps dTraf2, anticorps dtraf2, anticorps GB10539, anticorps fi15f02, anticorps wu:fi15f02, anticorps zgc:63704, anticorps TNF receptor associated factor 6, anticorps TNF receptor-associated factor 6, anticorps TNF receptor associated factor 6 L homeolog, anticorps TNF-receptor-associated factor 6, anticorps TNF receptor associated factor 6 S homeolog, anticorps TRAF6, anticorps Traf6, anticorps traf6.L, anticorps traf6, anticorps LOC551819, anticorps traf6.S
    Sujet
    TRAF6 is an E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. It also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. It may be essential for the formation of functional osteoclasts. It seems to also play a role in dendritic cells (DCs) maturation and/or activation. It represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. It regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation.
    Alias Symbols: MGC:3310, RNF85
    Protein Interaction Partner: YES1, UBE2V1, UBE2N, UBE2L3, UBE2E1, UBE2D2, UBE2D1, POLI, UBC, IL1R1, EDARADD, PLEKHF2, LAT, TRAF3IP2, PPP4R1, USP2, IKBKG, TRAF6, TRAF5, TRAF2, TRAF1, CNTN2, SYK, VPS52, PSEN1, LGMN, MEOX2, MCL1, CANX, nef, TAB2, OTUD7A, GTF2I, KRAS, DCBLD2, MAP3K7, EIF
    Protein Size: 522
    Poids moléculaire
    57 kDa
    ID gène
    7189
    NCBI Accession
    NM_004620, NP_004611
    UniProt
    Q9Y4K3
    Pathways
    Signalisation NF-kappaB, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Hepatitis C, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway
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