CTDSP2 anticorps (N-Term)

N° du produit ABIN503311

Détail du produit anti-CTDSP2 anticorps

Antigène: CTDSP2 (CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 2 (CTDSP2))

Épitope: N-Term

Reactivité: Humain, Rat, Souris, Cheval, Boeuf (Vache), Lapin, Cobaye, Chien, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CTDSP2 est non-conjugé

Application: Western Blotting (WB)

Séquence: MEHGSIITQA RREDALVLTK QGLVSKSSPK KPRGRNIFKA LFCCFRAQHV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against CTDSP2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human CTDSP2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 271 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur CTDSP2

Antigène: CTDSP2 (CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 2 (CTDSP2))

Autre désignation: CTDSP2 (CTDSP2 Produits)

Synonymes: anticorps fb16c04, anticorps wu:fb16c04, anticorps zgc:77714, anticorps MGC68415, anticorps CTDSP2, anticorps OS4, anticorps PSR2, anticorps SCP2, anticorps AI586070, anticorps D10Ertd73e, anticorps OS-4, anticorps CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2, anticorps CTD small phosphatase 2 L homeolog, anticorps CTD small phosphatase 2, anticorps ctdsp2, anticorps ctdsp2.L, anticorps CTDSP2, anticorps Ctdsp2

Sujet: CTDSP2 preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A.CTDSP2 negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. CTDSP2 is recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.CTDSP2 may contribute to the development of sarcomas.
Alias Symbols: OS4, PSR2, SCP2
Protein Interaction Partner: CDCA3, UBC, AR, SNAI1, POLR2A,
Protein Size: 271

Poids moléculaire: 31 kDa

ID gène: 10106

NCBI Accession: NM_005730, NP_005721

UniProt: O14595

Pathways: ER-Nucleus Signaling