LCK anticorps (N-Term)

N° du produit ABIN2785754

Cet anticorps Lapin Polyclonal détecte spécifiquement LCK dans WB. Il présente une réactivité envers Humain, Souris, Rat, Boeuf (Vache), Porc, Mouton, Lapin, Chien, Cheval et Cobaye.

Aperçu rapide pour LCK anticorps (N-Term) (ABIN2785754)

Antigène: LCK (Lymphocyte-Specific Protein tyrosine Kinase (LCK))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Porc, Mouton, Lapin, Chien, Cheval, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LCK est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-LCK anticorps

Épitope: N-Term

Séquence: ENCHYPIVPL DGKGTLLIRN GSEVRDPLVT YEGSNPPASP LQDNLVIALH

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 93%, Sheep: 100%

Attributs du produit: This is a rabbit polyclonal antibody against LCK. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human LCK

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur LCK

Antigène: LCK (Lymphocyte-Specific Protein tyrosine Kinase (LCK))

Autre désignation: LCK

Sujet: LCK is a member of the Src family of protein tyrosine kinases (PTKs). It is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. LCK localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules.
Protein Interaction Partner: LZTS2, CDKAL1, BAG6, UBC, WASL, WAS, env, SMAD3, SMAD2, MAPK1, HSP90AA1, Mbp, HAVCR2, PTPN22, G3BP1, nef, LAT, KHDRBS1, ADAM15, ZAP70, PAK2, LCK, CBL, SOCS3, SOCS2, SOCS1, IL2RB, CISH, YWHAQ, AJUBA, CD5, CBLB, SKAP1, SYK, SOS1, CD38, CD247, CD3E, FAM174A,
Protein Size: 363

Poids moléculaire: 39 kDa

ID gène: 3932

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Transition Metal Ion Homeostasis, Positive Regulation of Endopeptidase Activity, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling