PSMD10 anticorps (N-Term)

N° du produit ABIN2786728

Détail du produit anti-PSMD10 anticorps

Antigène: PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Poisson zèbre (Danio rerio), Lapin, Chien, Cobaye, Cheval, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PSMD10 est non-conjugé

Application: Western Blotting (WB)

Séquence: KERILADKSL ATRTDQDSRT ALHWACSAGH TEIVEFLLQL GVPVNDKDDA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against Psmd10. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide corresponding to a region of Mouse

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 231 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PSMD10

Antigène: PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))

Autre désignation: Psmd10 (PSMD10 Produits)

Synonymes: anticorps gankyrin, anticorps zgc:109707, anticorps dJ889N15.2, anticorps p28, anticorps p28(GANK), anticorps AW554874, anticorps p28Gank, anticorps proteasome 26S subunit, non-ATPase 10, anticorps proteasome (prosome, macropain) 26S subunit, non-ATPase, 10, anticorps psmd10, anticorps PSMD10, anticorps Psmd10

Sujet: Psmd10 acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly,Psmd10 is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module By similarity.Psmd10 acts as an oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression of this gene is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Psmd10 regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4.
Alias Symbols: AW554874
Protein Interaction Partner: Psmc4, Rb1, Cebpa, Cdk4,
Protein Size: 231

Poids moléculaire: 25 kDa

ID gène: 53380

NCBI Accession: NM_016883, NP_058579

UniProt: Q9Z2X2

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Ubiquitin Proteasome Pathway