GTPase NRas anticorps (Middle Region)

N° du produit ABIN2789436

Détail du produit anti-GTPase NRas anticorps

Antigène: GTPase NRas (NRAS)

Épitope: Middle Region

Reactivité: Humain, Rat, Souris, Chien, Boeuf (Vache), Cheval, Cobaye, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GTPase NRas est non-conjugé

Application: Western Blotting (WB)

Séquence: ADINLYREQI KRVKDSDDVP MVLVGNKCDL PTRTVDTKQA HELAKSYGIP

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against NRAS. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 189 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur GTPase NRas

Antigène: GTPase NRas (NRAS)

Autre désignation: NRAS (NRAS Produits)

Synonymes: anticorps NRAS, anticorps AV095280, anticorps N-ras, anticorps ALPS4, anticorps NRAS1, anticorps NS6, anticorps N-RAS, anticorps fj99a10, anticorps wu:fj99a10, anticorps zgc:100761, anticorps zras-b1, anticorps H-RAS, anticorps HRAS, anticorps GTPase NRas, anticorps neuroblastoma RAS viral (v-ras) oncogene homolog L homeolog, anticorps NRAS proto-oncogene, GTPase, anticorps neuroblastoma ras oncogene, anticorps neuroblastoma RAS viral oncogene homolog, anticorps Tsp_01117, anticorps nras.L, anticorps Nras, anticorps NRAS, anticorps nras

Sujet: This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.
Alias Symbols: ALPS4, N-ras, NRAS1, NS6
Protein Interaction Partner: UBC, MDM2, RGL2, VAT1, RNASEH2B, SPATS2, CD2AP, ELAVL1, SRI, RPS20, DNAJB1, EEF1A1, RAP1GDS1, RASGRP2, PLCE1, SMURF2, RASSF5, RACGAP1, SHOC2, SMAD4, ARHGAP4, PIK3CA, RAF1, BCL2, ACVR1, PIK3CG, MLLT4,
Protein Size: 189

Poids moléculaire: 21 kDa

ID gène: 4893

NCBI Accession: NM_002524, NP_002515

UniProt: P01111

Pathways: Signalisation p53, Signalisation MAPK, Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hepatitis C, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling