ASAP2 anticorps (N-Term)

N° du produit ABIN2790909

Détail du produit anti-ASAP2 anticorps

Antigène: ASAP2 (ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 2 (ASAP2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Cheval, Chien, Lapin, Porc, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ASAP2 est non-conjugé

Application: Western Blotting (WB)

Séquence: LSTDLHTIKQ AQDEERRQLI QLRDILKSAL QVEQKEDSQI RQSTAYSLHQ

Homologie: Dog: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 78%, Rat: 93%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against ASAP2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human ASAP2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1006 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur ASAP2

Antigène: ASAP2 (ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 2 (ASAP2))

Autre désignation: ASAP2 (ASAP2 Produits)

Synonymes: anticorps DDEF2, anticorps ddef2, anticorps asap2, anticorps si:dkey-37o8.2, anticorps AMAP2, anticorps CENTB3, anticorps PAG3, anticorps PAP, anticorps Pap-alpha, anticorps SHAG1, anticorps 6530401G17Rik, anticorps Ddef2, anticorps Gm1523, anticorps Gm592, anticorps ArfGAP with SH3 domain, ankyrin repeat and PH domain 2, anticorps ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 L homeolog, anticorps ArfGAP with SH3 domain, ankyrin repeat and PH domain 1b, anticorps ASAP2, anticorps asap2.L, anticorps asap1b, anticorps asap2, anticorps Asap2

Sujet: This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport.
Alias Symbols: AMAP2, CENTB3, DDEF2, PAG3, PAP, Pap-alpha, SHAG1
Protein Interaction Partner: SH3KBP1, MAP1LC3A, CTTN, Asap1, IKBKG, UBC, SUMO1, ELAVL1, ITSN1, THSD7A, GRB2, PACSIN3, PXN, BIN1, PTK2B, RAN, ARF6, REPS2, ARF5, ARF1, SRC, TBRG4,
Protein Size: 1006

Poids moléculaire: 112 kDa

ID gène: 8853

NCBI Accession: NM_003887, NP_003878

UniProt: O43150