ASAP2 anticorps (N-Term)

N° du produit ABIN7466765

Détail du produit anti-ASAP2 anticorps

Antigène: ASAP2 (ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 2 (ASAP2))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ASAP2 est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain, Souris

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the N-terminus region of human PAG3. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: Mouse brain , A431 , Raji

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.77 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur ASAP2

Antigène: ASAP2 (ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 2 (ASAP2))

Autre désignation: ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (ASAP2 Produits)

Synonymes: anticorps DDEF2, anticorps ddef2, anticorps asap2, anticorps si:dkey-37o8.2, anticorps AMAP2, anticorps CENTB3, anticorps PAG3, anticorps PAP, anticorps Pap-alpha, anticorps SHAG1, anticorps 6530401G17Rik, anticorps Ddef2, anticorps Gm1523, anticorps Gm592, anticorps ArfGAP with SH3 domain, ankyrin repeat and PH domain 2, anticorps ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 L homeolog, anticorps ArfGAP with SH3 domain, ankyrin repeat and PH domain 1b, anticorps ASAP2, anticorps asap2.L, anticorps asap1b, anticorps asap2, anticorps Asap2

Sujet: ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 , AMAP2 , CENTB3 , DDEF2 , PAG3 , PAP , Pap-alpha , SHAG1,This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Poids moléculaire: 112 kDa

ID gène: 8853

UniProt: O43150