DOK1 anticorps (C-Term)

N° du produit ABIN2792206

Détail du produit anti-DOK1 anticorps

Antigène: DOK1 (Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1))

Épitope: C-Term

Reactivité: Humain, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DOK1 est non-conjugé

Application: Western Blotting (WB)

Séquence: EPGTATGSGI KSHNSALYSQ VQKSGASGSW DCGLSRVGTD KTGVKSEGST

Homologie: Horse: 84%, Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against DOK1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human DOK1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 481 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur DOK1

Antigène: DOK1 (Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1))

Autre désignation: DOK1 (DOK1 Produits)

Synonymes: anticorps P62DOK, anticorps Dok-1, anticorps AW557123, anticorps p62DOK, anticorps dok1, anticorps zgc:76914, anticorps docking protein 1, anticorps docking protein 1b, anticorps DOK1, anticorps Dok1, anticorps dok1b

Sujet: DOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.
Alias Symbols: MGC117395, MGC138860, P62DOK
Protein Interaction Partner: UBC, RASA1, ABL1, CD28, Nck1, Syngap1, INSR, CRKL, BCR, Dlg4, gag-pol, ERBB2, VAV1, SRC, SHC1, PTK6, PIK3R1, ITK, FGR, CRK, ABL2, CBLL1, INPP5D, NCK2, MAP4K4, PTPRH, GRB10, TEC, ITGB2, SH2D1A, FES, PTPN6, ITGB3, PLCG1, LYN, KIT, YES1, RET, LCK, ITGB5, ITG
Protein Size: 481

Poids moléculaire: 53 kDa

ID gène: 1796

NCBI Accession: NM_001381, NP_001372

UniProt: Q99704