VISTA anticorps (Alexa Fluor 594)

N° du produit ABIN2808654

Détail du produit anti-VISTA anticorps (Alexa Fluor 594)

Antigène: VISTA (V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VISTA est conjugé à/à la Alexa Fluor 594

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SISP1/GI24

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur VISTA

Antigène: VISTA (V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA))

Autre désignation: GI24 (VISTA Produits)

Synonymes: anticorps MGC112715, anticorps MGC151567, anticorps B7-H5, anticorps B7H5, anticorps GI24, anticorps PP2135, anticorps SISP1, anticorps Dies1, anticorps VISTA, anticorps V-set immunoregulatory receptor, anticorps vsir, anticorps Vsir, anticorps VSIR

Sujet:

Synonyms: C10orf54, GI24_HUMAN, Platelet receptor Gi24, PP2135, SISP1, stress induced secreted protein 1, UNQ730/PRO1412.

Background: Platelet receptor GI24, also known as SISP1 or PP2135, is a 311 amino acid single-pass type I membrane protein that contains one Ig-like (immunoglobulin-like) domain. GI24 is thought to contribute to tumor-invasive growth in the collagen matrix and is encoded by a gene that maps to human chromosome 10q22.1. Chromosome 10 contains over 800 genes, 135 million nucleotides and comprises nearly 4.5 % of the human genome. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. The chromosome 10 encoded gene ERCC6 is important for DNA repair and is linked to Cockayne syndrome which is characterized by extreme photosensitivity and premature aging. Tetrahydrobiopterin deficiency and a number of syndromes involving defective skull and facial bone fusion are also linked to chromosome 10. As with most trisomies, trisomy 10 is rare and is deleterious.

Pathways: Cancer Immune Checkpoints