beta Arrestin 1 anticorps (pSer412) (Alexa Fluor 594)

N° du produit ABIN2810308

Détail du produit anti-beta Arrestin 1 anticorps (Alexa Fluor 594)

Antigène: beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

Épitope: pSer412

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp beta Arrestin 1 est conjugé à/à la Alexa Fluor 594

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Souris

Homologie: Human,Rat,Cow

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human beta-Arrestin 1 around the phosphorylation site of Ser412

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur beta Arrestin 1

Antigène: beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

Autre désignation: beta Arrestin 1 (ARRB1 Produits)

Synonymes: anticorps arrb1, anticorps MGC83787, anticorps arb1, anticorps arr1, anticorps barr1, anticorps betaarr1, anticorps 1200006I17Rik, anticorps AW208571, anticorps G430100A01Rik, anticorps ARB1, anticorps ARR1, anticorps BARRES, anticorps arrestin beta 1, anticorps arrestin, beta 1, anticorps arrestin beta 1 L homeolog, anticorps beta-arrestin 1, anticorps putative beta-arrestin 1, anticorps ARRB1, anticorps arrb1, anticorps arrb1.L, anticorps CpipJ_CPIJ016988, anticorps CpipJ_CPIJ017114, anticorps Smp_122900, anticorps Smp_126080, anticorps Smp_176980, anticorps Smp_152290, anticorps Arrb1

Sujet:

Synonyms: beta Arrestin 1 phospho S412, p-beta Arrestin 1 phospho S412, ARB 1, ARB1, ARR 1, ARR1, ARRB 1, ARRB1, Arrestin beta 1.

Background: Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. It mediates agonist dependent desensitization and internalization of G protein coupled receptors (GPCRs, e.g., beta 2 adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.

ID gène: 408

Pathways: Positive Regulation of Peptide Hormone Secretion, Nuclear Hormone Receptor Binding, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction