CAMK2B anticorps (AA 101-200) (Alexa Fluor 594)
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- Antigène Voir toutes CAMK2B Anticorps
- CAMK2B (Calcium/calmodulin-Dependent Protein Kinase II beta (CAMK2B))
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Épitope
- AA 101-200
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CAMK2B est conjugé à/à la Alexa Fluor 594
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Application
- Western Blotting (WB), Flow Cytometry (FACS)
- Specificité
- The peptide immunogen is highly conserved between CaMKII alpha, beta, gamma, and delta.
- Réactivité croisée
- Humain, Souris, Rat
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human CaMK2 alpha
- Isotype
- IgG
- Top Product
- Discover our top product CAMK2B Anticorps primaire
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- Indications d'application
- FCM 1:20-100
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- CAMK2B (Calcium/calmodulin-Dependent Protein Kinase II beta (CAMK2B))
- Autre désignation
- CaMK2 (CAMK2B Produits)
- Synonymes
- anticorps CAM2, anticorps CAMK2, anticorps CAMKB, anticorps Camk2d, anticorps Ck2b, anticorps camk2, anticorps camk2b, anticorps cam2, anticorps camkb, anticorps CAMK2B, anticorps calcium/calmodulin dependent protein kinase II beta, anticorps calcium/calmodulin-dependent protein kinase II, beta, anticorps calcium/calmodulin-dependent protein kinase II beta, anticorps calcium/calmodulin dependent protein kinase (CaM kinase) II alpha S homeolog, anticorps calcium/calmodulin dependent protein kinase (CaM kinase) II beta L homeolog, anticorps calcium/calmodulin-dependent protein kinase (CaM kinase) II beta, anticorps CAMK2B, anticorps Camk2b, anticorps camk2a.S, anticorps camk2b.L
- Sujet
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Synonyms: CAMK2B, Calcium/calmodulin-dependent protein kinase type II subunit beta, CaM kinase II subunit beta, CaMK-II subunit beta, CAM2, CAMK2, CAMKB, CAMK, CAMK-II, CAMKG, CAMK2G, CAMK2A, CAMK2D, CAMKD
Background: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
- ID gène
- 816
- UniProt
- Q13554
- Pathways
- Signalisation WNT, Interferon-gamma Pathway, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Smooth Muscle Cell Migration, Regulation of long-term Neuronal Synaptic Plasticity
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