WNT4 anticorps (Center)

N° du produit ABIN2854927

Détail du produit anti-WNT4 anticorps

Antigène: WNT4 (Wingless-Type MMTV Integration Site Family, Member 4 (WNT4))

Épitope: Center

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WNT4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Attributs du produit: Rabbit Polyclonal antibody to WNT4 (protein Wnt-4)
WNT4 antibody

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human WNT4. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:10000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:10000*

Commentaires:

Positive Control: 293T , HepG2 , WNT4 transfected 293T lysate , V5-human Wnt4-transfected 293T

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.78 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-WNT4 (ABIN2854927)

Bai, Huo, Chen, Guo, Xu, Fang, Zhang, Zhang: "Effect of Huayu Tongluo Herbs on Reduction of Proteinuria via Inhibition of Wnt/β-Catenin Signaling Pathway in Diabetic Rats." dans: Evidence-based complementary and alternative medicine : eCAM, Vol. 2017, pp. 3054145, (2017) (PubMed).

Détails sur WNT4

Antigène: WNT4 (Wingless-Type MMTV Integration Site Family, Member 4 (WNT4))

Autre désignation: WNT4 (WNT4 Produits)

Synonymes: anticorps CG4698, anticorps DWnt-4, anticorps DWnt4, anticorps Dm DWnt4, anticorps Dmel\\CG4698, anticorps Dwnt4, anticorps Wnt, anticorps Wnt-4, anticorps anon-EST:Liang-2.4, anticorps clone 2.4, anticorps wnt-4, anticorps wnt4, anticorps SERKAL, anticorps WNT-4, anticorps Xwnt4, anticorps xwnt-4, anticorps zgc:136737, anticorps Wnt family member 4, anticorps Wnt oncogene analog 4, anticorps wingless-type MMTV integration site family, member 4, anticorps wingless-type MMTV integration site family member 4 S homeolog, anticorps wingless-type MMTV integration site family, member 4a, anticorps WNT4, anticorps Wnt4, anticorps wnt4.S, anticorps wnt4a

Sujet: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98 % amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome.

Cellular Localization: Secreted , extracellular space , extracellular matrix

Poids moléculaire: 39 kDa

ID gène: 54361

Pathways: Signalisation WNT, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Cell-Cell Junction Organization, Tube Formation