Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Homologie
M, Rat
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogène
This WNT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242-269 amino acids from the C-terminal region of human WNT4.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Stockage commentaire
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Date de péremption
6 months
Beyer, Schramm, Akhmetshina, Dees, Kireva, Gelse, Sonnylal, de Crombrugghe, Taketo, Distler, Schett, Distler: "?-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis." dans: Annals of the rheumatic diseases, Vol. 71, Issue 5, pp. 761-7, (2012) (PubMed).
Antigène
WNT4
(Wingless-Type MMTV Integration Site Family, Member 4 (WNT4))
anticorps CG4698, anticorps DWnt-4, anticorps DWnt4, anticorps Dm DWnt4, anticorps Dmel\\CG4698, anticorps Dwnt4, anticorps Wnt, anticorps Wnt-4, anticorps anon-EST:Liang-2.4, anticorps clone 2.4, anticorps wnt-4, anticorps wnt4, anticorps SERKAL, anticorps WNT-4, anticorps Xwnt4, anticorps xwnt-4, anticorps zgc:136737, anticorps Wnt family member 4, anticorps Wnt oncogene analog 4, anticorps wingless-type MMTV integration site family, member 4, anticorps wingless-type MMTV integration site family member 4 S homeolog, anticorps wingless-type MMTV integration site family, member 4a, anticorps WNT4, anticorps Wnt4, anticorps wnt4.S, anticorps wnt4a
Sujet
The WNT family consists of secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. WNT4 is a protein which shows 98 % amino acid identity to the Wnt4 protein of mouse and rat. It play a concerted role in both the control of female development and the prevention of testes formation.