FRS2 anticorps (Center)

N° du produit ABIN2855603

Détail du produit anti-FRS2 anticorps

Antigène: FRS2 (Fibroblast Growth Factor Receptor Substrate 2 (FRS2))

Épitope: Center

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FRS2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Attributs du produit: Rabbit Polyclonal antibody to FRS2 (fibroblast growth factor receptor substrate 2)
FRS2 antibody

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human FRS2. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*

Commentaires:

Positive Control: H1299 , HeLaS3

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-FRS2 (ABIN2855603)

Bitzer, Spahn, Babaei, Horger, Singer, Schulze-Osthoff, Missios, Gatidis, Nann, Mattern, Scheble, Nikolaou, Armeanu-Ebinger, Schulze, Schroeder, Biskup, Beha, Claassen, Ruhm, Poso, Malek: "Targeting extracellular and juxtamembrane FGFR2 mutations in chemotherapy-refractory cholangiocarcinoma." dans: NPJ precision oncology, Vol. 5, Issue 1, pp. 80, (2021) (PubMed).

Détails sur FRS2

Antigène: FRS2 (Fibroblast Growth Factor Receptor Substrate 2 (FRS2))

Autre désignation: FRS2 (FRS2 Produits)

Synonymes: anticorps frs2, anticorps wu:fd21h10, anticorps zgc:91973, anticorps FRS2A, anticorps FRS2alpha, anticorps SNT, anticorps SNT-1, anticorps SNT1, anticorps 4732458E18, anticorps C330018A15Rik, anticorps Frs2alpha, anticorps fibroblast growth factor receptor substrate 2, anticorps fibroblast growth factor receptor substrate 2b, anticorps FRS2, anticorps frs2b, anticorps Frs2

Sujet: Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

Cellular Localization: Endomembrane system

Poids moléculaire: 57 kDa

ID gène: 10818

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Signaling Events mediated by VEGFR1 and VEGFR2