LIMK2 anticorps (pThr505)

N° du produit ABIN3020313

Détail du produit anti-LIMK2 anticorps

Antigène: LIMK2 (LIM Domain Kinase 2 (LIMK2))

Épitope: pThr505

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LIMK2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Phosphorylated Antibodies

Immunogène: A phospho specific peptide corresponding to residues surrounding T505 of human LIMK2

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:100 - 1:200

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur LIMK2

Antigène: LIMK2 (LIM Domain Kinase 2 (LIMK2))

Autre désignation: LIMK2 (LIMK2 Produits)

Synonymes: anticorps xlimk2, anticorps zgc:91990, anticorps wu:fa97c09, anticorps wu:fk73e11, anticorps LIMK2, anticorps Limk2b, anticorps Link2, anticorps LIMK, anticorps 9430059K01, anticorps A930024P04Rik, anticorps C85310, anticorps Limk2a, anticorps LIM domain kinase 2 L homeolog, anticorps LIM domain kinase 2, anticorps LIM motif-containing protein kinase 2, anticorps limk2.L, anticorps limk2, anticorps LIMK2, anticorps Limk2

Sujet: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.,LIMK2,Cancer,Tumor suppressors,p53 pathway,Signal Transduction,Kinase,Serine/threonine kinases,Cell Biology & Developmental Biology,Cytoskeleton,Microfilaments,TGF-b-Smad Signaling Pathway,Protein phosphorylation,LIMK2

Poids moléculaire: 69 kDa/72 kDa/77 kDa

ID gène: 3985

UniProt: P53671