TRAF6 anticorps (AA 263-522)

N° du produit ABIN3021194

Cet anticorps anti-TRAF6 est un anticorps Lapin Polyclonal détectant TRAF6 dans WB et IF. Adapté pour Humain. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour TRAF6 anticorps (AA 263-522) (ABIN3021194)

Antigène: TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRAF6 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-TRAF6 anticorps

Épitope: AA 263-522

Séquence: QENTQSHMRM LAQAVHSLSV IPDSGYISEV RNFQETIHQL EGRLVRQDHQ IRELTAKMET QSMYVSELKR TIRTLEDKVA EIEAQQCNGI YIWKIGNFGM HLKCQEEEKP VVIHSPGFYT GKPGYKLCMR LHLQLPTAQR CANYISLFVH TMQGEYDSHL PWPFQGTIRL TILDQSEAPV RQNHEEIMDA KPELLAFQRP TIPRNPKGFG YVTFMHLEAL RQRTFIKDDT LLVRCEVSTR FDMGSLRREG FQPRSTDAGV

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 263-522 of human TRAF6 (NP_004611.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-TRAF6 (ABIN3021194)

Teng, Luo, Yu, Chen, Huang, Chen, Xie, Zeng, Luo, Xiong, Liu, Hou, Feng: "CRISPR/Cas9-mediated deletion of miR-146a enhances antiviral response in HIV-1 infected cells." dans: Genes and immunity, (2018) (PubMed).

Détails sur TRAF6

Antigène: TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))

Autre désignation: TRAF6

Sujet: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported.,TRAF6,MGC:3310,RNF85,Cancer,Invasion and Metastasis,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Death receptors & ligands,Growth factor,TNF,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,Immunology & Inflammation,NF-kB Signaling Pathway,Toll-like Receptor Signaling Pathway,Cell Intrinsic Innate Immunity Signaling Pathway,TLR Signaling,TRAF6

Poids moléculaire: 59 kDa

ID gène: 7189

UniProt: Q9Y4K3

Pathways: Signalisation NF-kappaB, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Hepatitis C, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway