CDC42 anticorps (AA 25-191)

N° du produit ABIN3021671

Cet anticorps Lapin Polyclonal détecte spécifiquement CDC42 dans WB, IHC et IF. Il présente une réactivité avec des échantillons de Humain. Il a été cité dans 2+ publications.

Aperçu rapide pour CDC42 anticorps (AA 25-191) (ABIN3021671)

Antigène: CDC42 (Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDC42 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-CDC42 anticorps

Épitope: AA 25-191

Séquence: TNKFPSEYVP TVFDNYAVTV MIGGEPYTLG LFDTAGQEDY DRLRPLSYPQ TDVFLVCFSV VSPSSFENVK EKWVPEITHH CPKTPFLLVG TQIDLRDDPS TIEKLAKNKQ KPITPETAEK LARDLKAVKY VECSALTQKG LKNVFDEAIL AALEPPEPKK SRRCVLL

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 25-191 of human CDC42 (NP_001782.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-CDC42 (ABIN3021671)

Liu, Feng, Chen, Luo, Yan, Chen, Lin, Ding, Wen: "Dcf1 Triggers Dendritic Spine Formation and Facilitates Memory Acquisition." dans: Molecular neurobiology, Vol. 55, Issue 1, pp. 763-775, (2018) (PubMed).

Fang, Li, Han, Zhao, Gao, Yan, Luo: "Overexpression cdc42 attenuates isoflurane-induced neurotoxicity in developmental brain of rats." dans: Biochemical and biophysical research communications, Vol. 490, Issue 3, pp. 719-725, (2017) (PubMed).

Détails sur CDC42

Antigène: CDC42 (Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42))

Autre désignation: CDC42

Sujet: The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20.,CDC42,CDC42Hs,G25K,TKS,Epigenetics & Nuclear Signaling,Cancer,Signal Transduction,G protein signaling,Signal Transduction,Kinase,ErbB-HER Signaling Pathway,MAPK-JNK Signaling Pathway,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Cell Adhesion,Cytoskeleton,Microtubules,Actins,TGF-b-Smad Signaling Pathway,Immunology & Inflammation,Cytokines,B Cell Receptor Signaling Pathway,T Cell Receptor Signaling Pathway,CDC42

Poids moléculaire: 21 kDa

ID gène: 998

UniProt: P60953

Pathways: Signalisation MAPK, Dynamique des Microtubules, Signalisation RTK, Signalisation WNT, TCR Signaling, EGFR Signaling Pathway, Regulation of Actin Filament Polymerization, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Maintenance of Protein Location, Skeletal Muscle Fiber Development, Signaling Events mediated by VEGFR1 and VEGFR2, EGFR Downregulation, VEGF Signaling