LAMP3 anticorps

N° du produit ABIN3023873

Détail du produit anti-LAMP3 anticorps

Antigène: LAMP3 (Lysosomal-Associated Membrane Protein 3 (LAMP3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LAMP3 est non-conjugé

Application: Immunofluorescence (IF), Flow Cytometry (FACS)

Attributs du produit: This mAb recognizes protein of 26 kDa-60 kDa, which is identified as CD63/LAMP3. Its epitope is different from that of mAb LAMP3/803 or LAMP3/968 or NKI/C3 or MX-49.129.5. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63/LAMP3 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. It is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63/LAMP3 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. Deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.

Purification: Protein G affinity chromatography

Immunogène: Recombinant human protein was used as the immunogen for the LAMP3 antibody.

Clone: LAMP3-529

Isotype: IgG2a kappa

Information d'application

Indications d'application: Optimal dilution of the LAMP3 antibody should be determined by the researcher.\. Flow Cytometry: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the LAMP3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Détails sur LAMP3

Antigène: LAMP3 (Lysosomal-Associated Membrane Protein 3 (LAMP3))

Autre désignation: LAMP3 (LAMP3 Produits)

Synonymes: anticorps DC-LAMP, anticorps CD208, anticorps DC LAMP, anticorps DCLAMP, anticorps LAMP, anticorps LAMP-3, anticorps TSC403, anticorps 1200002D17Rik, anticorps Cd208, anticorps lysosomal associated membrane protein 3, anticorps lysosomal-associated membrane protein 3, anticorps LAMP3, anticorps Lamp3

Sujet: This mAb recognizes protein of 26  kDa-60  kDa, which is identified as CD63/LAMP3. Its epitope is different from that of mAb LAMP3/803 or LAMP3/968 or NKI/C3 or MX-49.129.5. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63/LAMP3 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. It is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63/LAMP3 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. Deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.