Thyroglobulin anticorps

N° du produit ABIN3023946

Détail du produit anti-Thyroglobulin anticorps

Antigène: Thyroglobulin (TG)

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Thyroglobulin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Protein G affinity chromatography

Immunogène: Human thyroid follicular cells were used as the immunogen for this Thyroglobulin antibody.

Clone: 2H11-6E1 or TGB04-TGB05

Isotype: IgG1 kappa

Information d'application

Indications d'application: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the antibody to be titered up or down for optimal performance.

1. Staining of formalin-fixed tissues requires boiling tissue sections in 10  mM citrate buffer,  pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.
2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Prediluted IHC only format : incubate for 30 min at RT (2)

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, *For IHC use only*

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Thyroglobulin antibody cocktail at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Détails sur Thyroglobulin

Antigène: Thyroglobulin (TG)

Autre désignation: Thyroglobulin (TG Produits)

Synonymes: anticorps TG, anticorps cb717, anticorps AITD3, anticorps TGN, anticorps Tgn, anticorps cog, anticorps thyroglobulin, anticorps TG, anticorps tg, anticorps LOC701526, anticorps LOC701756, anticorps LOC100434297, anticorps Tg

Sujet: Thyroglobulin is a 660  kDa dimeric pre-protein with mutiple glycosylation sites, detected at ~300  kDa in western blot. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for thyroglobulin antibody even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently thyroglobulin negative. Adenocarcinomas of nonthyroid origin do not react with this antibody cocktail. It is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the origin of the tumor. Thyroglobulin + calcitonin antibody, can identify medullary carcinomas of the thyroid. Furthermore, thyroglobulin + TTF1 antibody can be a reliable marker to differentiate between primary thyroid and lung neoplasms.

ID gène: 7038

Pathways: Thyroid Hormone Synthesis