CYLD anticorps

N° du produit ABIN3024584

Détail du produit anti-CYLD anticorps

Antigène: CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CYLD est non-conjugé

Application: Western Blotting (WB)

Purification: Protein A affinity chromatography

Immunogène: A recombinant protein fragment from the N-termiinal region of human CYLD was used as the immunogen for this antibody.

Isotype: IgG

Information d'application

Indications d'application: Provided assay concentrations are suggestions only, CYLD antibody titration may be required for optimal results.\. Western blot: 2-5 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: 0.5 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the CYLD antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur CYLD

Antigène: CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

Autre désignation: CYLD (CYLD Produits)

Synonymes: anticorps BRSS, anticorps CDMT, anticorps CYLD1, anticorps CYLDI, anticorps EAC, anticorps MFT, anticorps MFT1, anticorps SBS, anticorps TEM, anticorps USPL2, anticorps 2010013M14Rik, anticorps 2900009M21Rik, anticorps C130039D01Rik, anticorps mKIAA0849, anticorps cyld, anticorps LRRGT00003, anticorps Rp1, anticorps Rp1h, anticorps CYLD lysine 63 deubiquitinase, anticorps cylindromatosis (turban tumor syndrome), a, anticorps CYLD, anticorps Cyld, anticorps cylda

Sujet: CYLD is involved in multiple physiological processes including immune response, osteoclastogenesis and spermatogenesis. It is a tumor suppressor via its negative regulation of NF-kB activation. CYLD is a deubiquitinase, removing ubiquitin chains from tumor-necrosis factor receptor-associated factor 2 (TRAF2) and thereby preventing its activation of IkB, a regulator of NF-kB. NF-kB remains sequestered in the cytoplasm, unable to translocate to the nucleus and initiate cell survival and oncogenetic signaling.

ID gène: 1540

Pathways: Apoptose, Activation of Innate immune Response