c-MYC anticorps (AA 408-439)

N° du produit ABIN3026176

Cet anticorps anti-c-MYC Monoclonal Souris (Clone MYC699) (ABIN3026176) détecte spécifiquement c-MYC dans IF, ELISA et FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour c-MYC anticorps (AA 408-439) (ABIN3026176)

Antigène: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp c-MYC est non-conjugé

Application: Immunofluorescence (IF), ELISA, Flow Cytometry (FACS)

Classe de qualité: Carrier-free

Clone: MYC699

Détail du produit anti-c-MYC anticorps

Épitope: AA 408-439

Fonction: c-Myc Antibody (azide and preservative free)

Séquence: AEEQKLISEE DLLRKRREQL KHKLEQLRNS CA

Aucune reactivité croisée: Souris

Purification: Protein G affinity chromatography

Immunogène: Amino acids 408-439 (AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA) from the human protein were used as the immunogen for this c-Myc antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: The optimal dilution of the c-Myc antibody for each application should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the c-Myc antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur c-MYC

Antigène: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Autre désignation: c-Myc

Sujet: The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies also have shown that c-Myc is essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells, and which brought extensive attention in the development of new therapeutic approach for cancer treatment.

UniProt: P01106

Pathways: Signalisation p53, Cycle Cellulaire, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, L'effet Warburg