TRPC6 anticorps (Middle Region)

N° du produit ABIN3029233

Détail du produit anti-TRPC6 anticorps

Antigène: TRPC6 (Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRPC6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogène: An amino acid sequence from the middle region of human TRPC6 (HDYFCKCNDCNQKQKHD) was used as the immunogen for this TRPC6 antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the TRPC6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the TRPC6 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur TRPC6

Antigène: TRPC6 (Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6))

Autre désignation: TRPC6 (TRPC6 Produits)

Synonymes: anticorps FSGS2, anticorps TRP6, anticorps AV025995, anticorps LLHWJM002, anticorps LLHWJM003, anticorps LLHWJM004, anticorps TRP-6, anticorps Trrp6, anticorps mtrp6, anticorps trp6, anticorps bZ1P14.9, anticorps si:rp71-1p14.9, anticorps trpc6, anticorps transient receptor potential cation channel subfamily C member 6, anticorps transient receptor potential cation channel, subfamily C, member 6, anticorps transient receptor potential cation channel, subfamily C, member 6a, anticorps TRPC6, anticorps Trpc6, anticorps trpc6a, anticorps trpc6

Sujet: Transient receptor potential cation channel, subfamily C, member 6, also known as TRP6, is a transient receptor potentialion channel. Northern blot analysis revealed that TRPC6 is expressed primarily in placenta, lung, spleen, ovary, and small intestine. The protein is a nonselective cation channel that is activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Although TRPC3, the closest structural relative of TRPC6, is activated in the same manner, human TRPC1 and mouse Trpc4 and Trpc5 were unresponsive to DAG. Immunofluorescence studies showed that most TRPC6 expression is confined to podocytes. It is also expressed in glomerular endothelial cells. Cardiac-specific overexpression of the protein in transgenic mice resulted in heightened sensitivity to stress, a propensity for lethal cardiac growth and heart failure, and an increase in Nfat-dependent expression of beta-myosin heavy chain(MYH7), a marker for pathologic hypertrophy. Studies of Trpc6 -/- mice showed that it has a role in regulation of smooth muscle tone in blood vessels and lung.

UniProt: Q9Y210