c-MYC anticorps (AA 257-439)

N° du produit ABIN3029536

Cet anticorps Lapin Polyclonal détecte spécifiquement c-MYC dans WB et IF. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour c-MYC anticorps (AA 257-439) (ABIN3029536)

Antigène: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp c-MYC est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-c-MYC anticorps

Épitope: AA 257-439

Fonction: c-Myc Antibody

Purification: Antigen affinity

Immunogène: Human partial recombinant protein (AA 257-439) was used as the immunogen for this c-Myc antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the c-Myc antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the c-Myc antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur c-MYC

Antigène: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Autre désignation: c-Myc

Sujet: C-Myc is an oncogene that functions both in the stimulation of cell proliferation and in apoptosis. It elicits its oncogenic activity by causing immortalization, and to a lesser extent the transformation of cells, in addition to several other mechanisms. The proto-oncogene encodes a transcription factor that is critical for cell growth and proliferation. It is one of the genes frequently altered in cancer cells in which it exhibits constitutive activity. Downregulation of the protein is critical for 2-Methoxyestradiol (2ME2)-induced oxidative stress and apoptosis in AML cells. And its up-regulation is important for promoting lymphocyte cell division, and demonstrating that GFP-c-Myc expression is a marker of proliferating lymphocytes in vivo.

Pathways: Signalisation p53, Cycle Cellulaire, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, L'effet Warburg