ABCG1 anticorps (C-Term)

N° du produit ABIN3030057

Détail du produit anti-ABCG1 anticorps

Antigène: ABCG1 (ATP-Binding Cassette, Sub-Family G (WHITE), Member 1 (ABCG1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ABCG1 est non-conjugé

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogène: An amino acid sequence from the C-terminus of human ABCG1 (ETCHFQKSEAILRELDVENAK) was used as the immunogen for this ABCG1 antibody (100% homologous in human, mouse and rat).

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the ABCG1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the ABCG1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur ABCG1

Antigène: ABCG1 (ATP-Binding Cassette, Sub-Family G (WHITE), Member 1 (ABCG1))

Autre désignation: ABCG1 (ABCG1 Produits)

Synonymes: anticorps ABCG1, anticorps zgc:162197, anticorps ABC8, anticorps WHITE1, anticorps AW413978, anticorps Abc8, anticorps White, anticorps ATP binding cassette subfamily G member 1, anticorps ATP-binding cassette, sub-family G (WHITE), member 1, anticorps ABCG1, anticorps abcg1, anticorps Abcg1

Sujet: ABCG1 (ATP-binding cassette, subfamily G, member 1) also known as ABC8, is a protein that in humans is encoded by the ABCG1 gene. ABCG1 is a regulator of macrophage cholesterol and phospholipid transport. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. The gene is mapped on 21q22.3. This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. ABCG1 is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein. Inhibition of ABCG1 protein expression using an antisense strategy resulted in reduced HDL3-dependent efflux of cholesterol and choline-phospholipids. In macrophages, silencing of GPS2 by RNA interference reducedABCG1expression and diminished ABCG1-mediated cholesterol efflux.

UniProt: P45844

Pathways: Lipid Metabolism