CD68 anticorps (AA 312-326)

N° du produit ABIN3030412

Détail du produit anti-CD68 anticorps

Antigène: CD68 (CD68 Molecule (CD68))

Épitope: AA 312-326

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD68 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Purification: Antigen affinity

Immunogène: Amino acids 312-326 (AFCITRRRQSTYQPL-mouse) were used as the immunogen for this CD68 antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the CD68 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,IHC (Frozen): 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the CD68 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Références pour anticorps anti-CD68 (ABIN3030412)

Minasyan, Sharma, Pivarnik, Liu, Adams, Bermejo, Peng, Liu, Ishikawa, Perry, Kaminski, Gulati, Herzog, Dela Cruz, Ryu: "Elevated IL-15 concentrations in the sarcoidosis lung is independent of granuloma burden and disease phenotypes." dans: American journal of physiology. Lung cellular and molecular physiology, (2021) (PubMed).

Han, Qian, Jiang, Figetakis, Kosyakova, Tellides, Niklason, Chang: "A therapeutic vascular conduit to support in vivo cell-secreted therapy." dans: NPJ Regenerative medicine, Vol. 6, Issue 1, pp. 40, (2021) (PubMed).

Détails sur CD68

Antigène: CD68 (CD68 Molecule (CD68))

Autre désignation: CD68 (CD68 Produits)

Synonymes: anticorps Lamp4, anticorps Scard1, anticorps gp110, anticorps GP110, anticorps LAMP4, anticorps SCARD1, anticorps CD68 molecule, anticorps CD68 antigen, anticorps Cd68 molecule, anticorps CD68, anticorps Cd68

Sujet: Cluster of differentiation 68 is a transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. CD68 is a member of a family of hematopoietic mucin-like molecules that includes leukosialin/CD43 and stem cell antigen CD34. The gene is mapped to 17p13.1. Immunohistochemistry can be used to identify the presence of CD68, which is found in the cytoplasmic granules of a range of different blood cells. It is particularly useful as a marker for the various cells of the macrophage lineage, including monocytes, histiocytes, giant cells, Kupffer cells, and osteoclasts. This allows it to be used to distinguish diseases of otherwise similar appearance, such as the monocyte/macrophage and lymphoid forms of leukaemia(the latter being CD68 negative). Its presence in macrophages also makes it useful in diagnosing conditions related to proliferation or abnormality of these cells, such as malignant histiocytosis, histiocytic lymphoma, and Gaucher's disease.

UniProt: P31996