DISC1 anticorps (Middle Region)

N° du produit ABIN3030744

Détail du produit anti-DISC1 anticorps

Antigène: DISC1 (Disrupted in Schizophrenia 1 (DISC1))

Épitope: Middle Region

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DISC1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogène: An amino acid sequence from the middle region of human Disrupted in Schizophrenia 1 (EKQQLQKEIEALQARMF) was used as the immunogen for this DISC1 antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the DISC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,Mouse

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the DISC1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur DISC1

Antigène: DISC1 (Disrupted in Schizophrenia 1 (DISC1))

Autre désignation: DISC1 (DISC1 Produits)

Synonymes: anticorps DISC1, anticorps C1orf136, anticorps SCZD9, anticorps disrupted in schizophrenia 1, anticorps disrupted in schizophrenia 1 protein, anticorps disc1, anticorps DISC1, anticorps LOC100580606, anticorps Disc1

Sujet: Disrupted in Schizophrenia 1 is a protein that is encoded by the DISC1 gene in humans. Ma et al.(2002) determined that the mouse gene maps to chromosome 8 in a region with homology of synteny to human chromosome 1q42. Ozeki et al.(2003) demonstrated that rodent Disc1 expression displayed pronounced developmental regulation, with the highest levels in late embryonic life during development of the cerebral cortex. Millar et al.(2005) showed that the protein interacts with the UCR2 domain of phosphodiesterase-4B, implicated in susceptibility to schizophrenia, and that elevation of cellular cAMP leads to dissociation of PDE4B from DISC1 and in increase in PDE4B activity.

UniProt: Q9NRI5

Pathways: Regulation of Cell Size