Oncostatin M anticorps (Middle Region)

N° du produit ABIN3032094

Détail du produit anti-Oncostatin M anticorps

Antigène: Oncostatin M (OSM)

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Oncostatin M est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogène: An amino acid sequence from the middle region of human Oncostatin M (ASDAFQRKLEGCRFLHGY) was used as the immunogen for this Oncostatin M antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the Oncostatin M antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the Oncostatin M antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur Oncostatin M

Antigène: Oncostatin M (OSM)

Autre désignation: Oncostatin M (OSM Produits)

Synonymes: anticorps OSM, anticorps OncoM, anticorps oncostatin M, anticorps OSM, anticorps Osm

Sujet: Oncostatin M (OSM) is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM has the ability to inhibit the growth of human A375 melanoma cells but not normal human fibroblasts. Treatment with recombinant OSM leads to the inhibition of proliferation and changes in cellular morphology of a number of tumor cell lines derived from a wide variety of tissue types. OSM also has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells, a function shared by LIF, CSF3, and IL6.

UniProt: P13725

Pathways: Signalistation JAK/STAT, Negative Regulation of Hormone Secretion