RIPK1 anticorps (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1) (AA 316-671)

Details for Product anti-RIPK1 Antibody No. ABIN3042480
Antigène
  • RIP
  • RIP1
  • D330015H01Rik
  • Rinp
  • Rip1
  • rip1
  • ripk1
  • xRIP1beta
  • xrip1
  • receptor interacting serine/threonine kinase 1
  • receptor (TNFRSF)-interacting serine-threonine kinase 1
  • receptor interacting serine/threonine kinase 1 L homeolog
  • RIPK1
  • Ripk1
  • ripk1.L
Épitope
AA 316-671
18
13
8
8
8
7
7
4
4
4
4
4
3
2
2
2
2
2
2
2
1
1
1
1
1
Reactivité
Humain
165
58
47
8
4
3
3
1
1
Hôte
Lapin
137
31
3
Clonalité
Polyclonal
Conjugué
Cet anticorp RIPK1 est non-conjugé
10
6
6
6
5
5
5
5
5
3
2
2
2
1
1
1
1
Application
Western Blotting (WB)
113
56
55
27
24
16
5
4
4
2
2
2
1
Options
Fonction Rabbit IgG polyclonal antibody for Receptor-interacting serine/threonine-protein kinase 1(RIPK1) detection. Tested with WB in Human.
Immunogène E.coli-derived human RIP recombinant protein (Position: K316-N671). Human RIP shares 65% amino acid (aa) sequence identity with mouse RIP.
Isotype IgG
Réactivité croisée (Details) No cross reactivity with other proteins.
Attributs du produit Rabbit IgG polyclonal antibody for Receptor-interacting serine/threonine-protein kinase 1(RIPK1) detection. Tested with WB in Human.
Gene Name: receptor (TNFRSF)-interacting serine-threonine kinase 1
Protein Name: Receptor-interacting serine/threonine-protein kinase 1
Purification Immunogen affinity purified.
Plasmids, Primers & others Plasmids, Primers & others RIPK1 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation RIPK1 (RIPK1 Antibody Extrait)
Sujet RIPK1, also known as RIP or RIP1, is an enzyme that in humans is encoded by the RIPK1 gene. It is mapped to 6p25.2. RIPK1 is a key signaling molecule in the programmed necrosis pathway, which plays important roles in development, tissue damage response, and antiviral immunity. RIPK1 is known to have function in a variety of cellular pathways including the NF-κB pathway and programmed necrotic cell death (necroptosis). The kinase domain, while important for necroptotic (programmed necrotic) functions, it appears dispensable for other lethal, as well as pro-survival roles. Also, proteolytic processing of RIPk1, through both caspase-dependent and -independent mechanisms, triggers lethality that is dependent on the generation of one or more specific C-terminal cleavage product(s) of RIPk1 upon stress.

Synonyms: Cell death protein RIP antibody|FLJ39204 antibody|OTTHUMP00000039163 antibody|Receptor (TNFRSF) interacting serine threonine kinase 1 antibody|receptor interacting protein 1 antibody|Receptor interacting protein antibody|Receptor interacting serine threonine protein kinase 1 antibody|Receptor TNFRSF interacting serine threonine kinase 1 antibody|Receptor-interacting protein 1 antibody|Receptor-interacting serine/threonine-protein kinase 1 antibody|Rinp antibody|RIP 1 antibody|RIP antibody|Rip-1 antibody|RIP1 antibody|RIPK 1 antibody|Ripk1 antibody|RIPK1_HUMAN antibody|Serine threonine protein kinase RIP antibody|Serine/threonine-protein kinase RIP antibody
ID gène 8737
UniProt Q13546
Pathways Signalisation NF-kappaB, Apoptose, Caspase Cascade in Apoptosis, Signalisation TLR, Activation of Innate immune Response, Inositol Metabolic Process, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling
Indications d'application WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for RIP is approximately 0.25 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.
Commentaires

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
Concentration 500 μg/mL
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freezing and thawing.
Stock 4 °C/-20 °C
Stockage commentaire At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
Images (Fournisseur)
Western Blotting (WB) image for anti-Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) (AA 316-671) antibody (ABIN3042480) Anti-RIP Picoband antibody, All lanes: Anti RIP at 0.5ug/ml WB: Recombinant Human R...
Western Blotting (WB) image for anti-Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) (AA 316-671) antibody (ABIN3042480) Observed bind size: 76KD
Produit citée dans: Wang, Ma, Hu, Xie, Wu, Zeng, Song: "Bifidobacterial recombinant thymidine kinase-ganciclovir gene therapy system induces FasL and TNFR2 mediated antitumor apoptosis in solid tumors." dans: BMC cancer, Vol. 16, pp. 545, 2017 (PubMed).

Chen, Zhao, Wu, Zou, Luo, Li, Xie, Liang: "The role of RIP1 and RIP3 in the development of aplastic anemia induced by cyclophosphamide and busulphan in mice." dans: International journal of clinical and experimental pathology, Vol. 7, Issue 12, pp. 8411-20, 2015 (PubMed).

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