Serotonin Receptor 2B anticorps (C-Term)

N° du produit ABIN3042730

Cet anticorps Lapin Polyclonal détecte spécifiquement Serotonin Receptor 2B dans WB. Il présente une réactivité envers Humain et Rat.

Aperçu rapide pour Serotonin Receptor 2B anticorps (C-Term) (ABIN3042730)

Antigène: Serotonin Receptor 2B (HTR2B)

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Serotonin Receptor 2B est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Serotonin Receptor 2B anticorps

Épitope: AA 446-478, C-Term

Fonction: Anti-5HT2B Receptor/HTR2B Antibody Picoband®

Séquence: MRLRSSTIQS SSIILLDTLL LTENEGDKTE EQ

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-5HT2B Receptor/HTR2B Antibody Picoband® (ABIN3042730). Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human 5HT2B Receptor, different from the related mouse sequence by six amino acids, and from the related rat sequence by nine amino acids.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL, Human, Rat
1. "Entrez Gene: HTR2B 5-hydroxytryptamine (serotonin) receptor 2B". 2. Doly S, Valjent E, Setola V, Callebert J, Hervé D, Launay JM, Maroteaux L (Mar 2008). "Serotonin 5-HT2B receptors are required for 3,4-methylenedioxymethamphetamine-induced hyperlocomotion and 5-HT release in vivo and in vitro". The Journal of Neuroscience28 (11): 2933-40. 3. Schmuck K, Ullmer C, Engels P, Lübbert H (Mar 1994). "Cloning and functional characterization of the human 5-HT2B serotonin receptor". FEBS Letters 342 (1): 85-90.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur Serotonin Receptor 2B

Antigène: Serotonin Receptor 2B (HTR2B)

Autre désignation: HTR2B

Sujet:

Synonyms: 5-hydroxytryptamine receptor 2B,5-HT-2B,5-HT2B,Serotonin receptor 2B,HTR2B,

Tissue Specificity: Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex. .

Background: 5HT2B Receptor is known as HTR2B. This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved.

Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.

Poids moléculaire: 54 kDa

ID gène: 3357

UniProt: P41595

Pathways: Signalistation JAK/STAT, Inositol Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Carbohydrate Metabolic Process