PCSK4 anticorps (N-Term)

N° du produit ABIN3042910

Détail du produit anti-PCSK4 anticorps

Antigène: PCSK4 (Proprotein Convertase Subtilisin/kexin Type 4 (PCSK4))

Épitope: AA 117-133, N-Term

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PCSK4 est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit IgG polyclonal antibody for Proprotein convertase subtilisin/kexin type 4(PCSK4) detection. Tested with WB in Mouse,Rat.

Séquence: DPWFSKQWYM NKEIQQD

Réactivité croisée (Details): Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Attributs du produit: Rabbit IgG polyclonal antibody for Proprotein convertase subtilisin/kexin type 4(PCSK4) detection. Tested with WB in Mouse,Rat.
Gene Name: proprotein convertase subtilisin/kexin type 4
Protein Name: Proprotein convertase subtilisin/kexin type 4

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of mouse Proprotein convertase PC4(117-133aa DPWFSKQWYMNKEIQQD), different from the related rat sequence by one amino acid.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat, Predicted Species: Mouse
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur PCSK4

Antigène: PCSK4 (Proprotein Convertase Subtilisin/kexin Type 4 (PCSK4))

Autre désignation: PCSK4 (PCSK4 Produits)

Synonymes: anticorps PC4, anticorps SPC5, anticorps AI647044, anticorps L21221, anticorps NEC 3, anticorps NEC3, anticorps PCSK4, anticorps pc4, anticorps spc5, anticorps MGC146505, anticorps pcsk4, anticorps proprotein convertase subtilisin/kexin type 4, anticorps proprotein convertase subtilisin/kexin type 4 L homeolog, anticorps PCSK4, anticorps Pcsk4, anticorps pcsk4, anticorps pcsk4.L

Sujet: PCSK4(Proprotein Convertase, Subtilisin/Kexin-Type, 4), is an enzyme that in humans is encoded by the PCSK4 gene. The gene for PC4(Pcsk4 locus) was mapped to mouse chromosome 10, close to the adipsin locus and near the gene encoding anti-mullerian hormone. Qiu et al.(2005) found that aberrant processing of pro-IGF2 by PC4 may be a cause of IUGR. PC4 cleaved pro-IGF2 to generate the intermediate processed form, IGF2(1-102). Mature IGF2(1-67), likely resulting from further processing by carboxypeptidases, is capable of activating invasive trophoblast cells through AKT phosphorylation. Inhibition of PC4 by a PC4-specific inhibitor blocked pro-IGF2 processing and reduced trophoblast cell migration.

Synonyms: PC4 antibody|PCSK4 antibody|PCSK4_HUMAN antibody|Proprotein convertase 4 antibody|Proprotein convertase PC4 antibody|Proprotein convertase subtilisin/kexin type 4 antibody|SPC5 antibody

UniProt: P29121