CXCR4 anticorps (N-Term)

N° du produit ABIN3042911

Détail du produit anti-CXCR4 anticorps

Antigène: CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))

Épitope: AA 31-43, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CXCR4 est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit IgG polyclonal antibody for C-X-C chemokine receptor type 4(CXCR4) detection. Tested with WB in Human.

Séquence: EENANFNKIF LPT

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for C-X-C chemokine receptor type 4(CXCR4) detection. Tested with WB in Human.
Gene Name: chemokine(C-X-C motif) receptor 4
Protein Name: C-X-C chemokine receptor type 4

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human CXCR4(31-43aa EENANFNKIFLPT).

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Références pour anticorps anti-CXCR4 (ABIN3042911)

Zhang, Wang, Yue, Liu, Liu: "Construction of a CXCL12-KDEL fusion gene to inhibit head and neck squamous cell carcinoma metastasis by intracellular sequestration of CXCR4." dans: BioMed research international, Vol. 2015, pp. 195828, (2015) (PubMed).

Zhu, Sun, Tan, Xu, Dai, Wang, Fan, Zhou: "Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF‑1α expression in vivo." dans: Molecular medicine reports, Vol. 10, Issue 2, pp. 585-92, (2015) (PubMed).

Liu, Wang, Wang, Wang: "Anticancer effects of chemokine receptor 4(CXCR4) gene silenced by CXCR4-siRNA in nude mice model of ovarian cancer." dans: Cell biochemistry and biophysics, Vol. 70, Issue 3, pp. 1893-900, (2014) (PubMed).

Li, Chen, Yuan, Zhou, He, Zu, Qi: "CXCR4 expression in bladder transitional cell carcinoma and its relationship with clinicopathological features." dans: Urologia internationalis, Vol. 92, Issue 2, pp. 157-63, (2014) (PubMed).

Tan, Chang, Liu, Tang: "Silencing of CXCR4 inhibits tumor cell proliferation and neural invasion in human hilar cholangiocarcinoma." dans: Gut and liver, Vol. 8, Issue 2, pp. 196-204, (2014) (PubMed).

Wang, Guo, Han, Xu, Guo, Sun: "Distinct roles of different fragments of PDCD4 in regulating the metastatic behavior of B16 melanoma cells." dans: International journal of oncology, Vol. 42, Issue 5, pp. 1725-33, (2013) (PubMed).

Chen, Wang, Wang, Zhang, Liu, Pan, Wang, Chen, Jin, Wang: "Effect of short hairpin RNA-induced CXCR4 silence on ovarian cancer cell." dans: Biomedicine & pharmacotherapy = Biome?decine & pharmacothe?rapie, Vol. 66, Issue 7, pp. 549-53, (2012) (PubMed).

Lin, Zheng, Shen, Tang, Chen, Sun, Zhao, Yao: "Relationships between levels of CXCR4 and VEGF and blood-borne metastasis and survival in patients with osteosarcoma." dans: Medical oncology (Northwood, London, England), Vol. 28, Issue 2, pp. 649-53, (2011) (PubMed).

Wang, Cai, Han, Yang, Tong, Cao, Wu, Wang: "Silencing of CXCR4 blocks progression of ovarian cancer and depresses canonical Wnt signaling pathway." dans: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, Vol. 21, Issue 6, pp. 981-7, (2011) (PubMed).

Li, Deng, Gong, Bian, Dai, Wang: "Upregulation of CXCR4 favoring neural-like cells migration via AKT activation." dans: Neuroscience research, Vol. 67, Issue 4, pp. 293-9, (2010) (PubMed).

Zhang, Qi, Li, Zhang, Xu, Wang, Sun: "Chemokine CXCL12 and its receptor CXCR4 expression are associated with perineural invasion of prostate cancer." dans: Journal of experimental & clinical cancer research : CR, Vol. 27, pp. 62, (2009) (PubMed).

Détails sur CXCR4

Antigène: CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))

Autre désignation: CXCR4 (CXCR4 Produits)

Synonymes: anticorps CD184, anticorps D2S201E, anticorps FB22, anticorps HM89, anticorps HSY3RR, anticorps LAP3, anticorps LCR1, anticorps LESTR, anticorps NPY3R, anticorps NPYR, anticorps NPYRL, anticorps NPYY3R, anticorps WHIM, anticorps Cmkar4, anticorps PB-CKR, anticorps PBSF/SDF-1, anticorps Sdf1r, anticorps CXC-R4-B, anticorps CXCR-4-B, anticorps cd184, anticorps cxcr4, anticorps fb22, anticorps hm89, anticorps hsy3rr, anticorps lap3, anticorps lcr1, anticorps lestr, anticorps npy3r, anticorps npyr, anticorps npyrl, anticorps npyy3r, anticorps xcxcr4, anticorps CXC-R4, anticorps CXCR-4, anticorps d2s201e, anticorps whim, anticorps CXC-R4-A, anticorps CXCR-4-A, anticorps xCXCR4, anticorps CXCR4, anticorps cb403, anticorps zgc:109863, anticorps cb824, anticorps C-X-C motif chemokine receptor 4, anticorps chemokine (C-X-C motif) receptor 4, anticorps C-X-C motif chemokine receptor 4 S homeolog, anticorps C-X-C chemokine receptor type 4, anticorps C-X-C motif chemokine receptor 4 L homeolog, anticorps chemokine (C-X-C motif), receptor 4b, anticorps chemokine (C-X-C motif) receptor 4a, anticorps CXCR4, anticorps Cxcr4, anticorps cxcr4.S, anticorps cxcr4, anticorps LOC100049444, anticorps cxcr4.L, anticorps cxcr4b, anticorps cxcr4a

Sujet: CXCR4 (Chemokine,CXC Motif, Receptor 4), also known as FUSIN or NPY3R, is a protein that in humans is encoded by the CXCR4 gene. It is the receptor for the CXC chemokine SDF1 that has essential functions on embryo organogenesis, immunological functions and T lymphocyte trafficking. CXCR4 is the only SDF1 receptor identified so far. This suggests that CXCR4 expression is critical for the biological effects of SDF1. CXCR4 is also a seven-transmembrane-spanning, G-protein-coupled receptor for the CXC chemokine PBSF/SDF-1. It functions as a co-receptor for T-cell-line tropic human immunodeficiency virus HIV-1. It was concluded that PBSF/SDF-1 and CXCR4 define a new signalling system for organ vascularization.

Synonyms: C-X-C chemokine receptor type 4 antibody|CD184 antibody|CD184 antigen antibody|Chemokine(C X C motif) receptor 4 antibody|Chemokine CXC Motif Receptor 4 antibody|CXC-R4 antibody|CXCR-4 antibody|CXCR4 antibody|CXCR4_HUMAN antibody|D2S201E antibody|FB22 antibody|Fusin antibody|HM89 antibody|HSY3RR antibody|LAP 3 antibody|LAP3 antibody|LCR1 antibody|LESTR antibody|Leukocyte derived seven transmembrane domain receptor antibody|Leukocyte-derived seven transmembrane domain receptor antibody|Lipopolysaccharide associated protein 3 antibody|Neuropeptide Y receptor Y3 antibody|NPY3R antibody|NPYR antibody|NPYRL antibody|NPYY3 antibody|NPYY3R antibody|Probable G protein coupled receptor lcr1 homolog antibody|SDF 1 receptor antibody|SDF-1 receptor antibody|SEVEN-TRANSMEMBRANE-SEGMENT RECEPTOR antibody|Stromal cell derived factor 1 receptor antibody|Stromal cell-derived factor 1 receptor antibody|WHIM antibody

UniProt: P61073

Pathways: Regulation of Cell Size, CXCR4-mediated Signaling Events