CYP11B1 anticorps (C-Term)

N° du produit ABIN3043091

Détail du produit anti-CYP11B1 anticorps

Antigène: CYP11B1 (Cytochrome P450, Family 11, Subfamily B, Polypeptide 1 (CYP11B1))

Épitope: AA 436-450, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CYP11B1 est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit IgG polyclonal antibody for Cytochrome P450 11B1, mitochondrial(CYP11B1) detection. Tested with WB in Human.

Séquence: RNFYHVPFGF GMRQC

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Cytochrome P450 11B1, mitochondrial(CYP11B1) detection. Tested with WB in Human.
Gene Name: cytochrome P450, family 11, subfamily B, polypeptide 1
Protein Name: Cytochrome P450 11B1, mitochondrial

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human CYP11B1(436-450aa RNFYHVPFGFGMRQC).

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur CYP11B1

Antigène: CYP11B1 (Cytochrome P450, Family 11, Subfamily B, Polypeptide 1 (CYP11B1))

Autre désignation: CYP11B1 (CYP11B1 Produits)

Synonymes: anticorps CPN1, anticorps CYP11B, anticorps FHI, anticorps P450C11, anticorps AA389061, anticorps Cyp11b, anticorps Cyp11b-1, anticorps Cp11ba, anticorps RATCP11BA, anticorps P450c11, anticorps cytochrome P450, family 11, subfamily B, polypeptide 1, anticorps cytochrome P450 family 11 subfamily B member 1, anticorps cytochrome P450, family 11, subfamily b, polypeptide 1, anticorps cytochrome P450, subfamily XI B, polypeptide 1, anticorps CYP11B1, anticorps Cyp11b1

Sujet: CYP11B1(Cytochrome p450, family 11, subfamily B, polypeptide 1), also called Steroid 11-beta-hydroxylase or P450C11, is a steroid hydroxylase found in the zona fasciculata. The CYP11B1 gene functions primarily in mitochondria in the zona fasciculata of the adrenal cortex to convert 11-deoxycortisol to cortisol and 11-deoxycorticosterone to corticosterone. CYP11B1 is a member of the cytochrome P450 superfamily of enzymes. It is mapped on 8q24.3. The CYP11B1 gene contains 9 exons and spans 6.5 kb. Using RT-PCR, Kayes-Wandover and White detected CYP11B1 mRNA in human cardiac tissue samples from left and right atria, aorta, apex, intraventricular septum, and atrioventricular node, as well as whole adult and fetal heart. Ventricles did not express CYP11B1. In patients with 11-beta-hydroxylase deficiency leading to hypertension and congenital adrenal hyperplasia, Pascoe et al. identified mutations in the CYP11B1 gene.

Synonyms: CPN1 antibody|CYP11B antibody|CYPXIB1 antibody|Cytochrome P 450c11 antibody|Cytochrome P450 11B1, mitochondrial antibody|Cytochrome p450 XIB1 antibody|Cytochrome P450, family 11, subfamily B, polypeptide 1 antibody|Cytochrome P450, subfamily XIB(steroid 11 beta hydroxylase), polypeptide 1 antibody|Cytochrome P450C11 antibody|FHI antibody|P 450C11 antibody|P450C11 antibody|S11BH antibody|Steroid 11 beta hydroxylase antibody|Steroid 11 beta monooxygenase antibody

UniProt: P15538

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, Regulation of Systemic Arterial Blood Pressure by Hormones, C21-Steroid Hormone Metabolic Process, Carbohydrate Homeostasis