Survivin anticorps (C-Term)

N° du produit ABIN3043195

Détail du produit anti-Survivin anticorps

Antigène: Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))

Épitope: AA 121-142, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Survivin est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit IgG polyclonal antibody for Baculoviral IAP repeat-containing protein 5(BIRC5) detection. Tested with WB in Human.

Séquence: KKEFEETAKK VRRAIEQLAA MD

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Baculoviral IAP repeat-containing protein 5(BIRC5) detection. Tested with WB in Human.
Gene Name: baculoviral IAP repeat containing 5
Protein Name: Baculoviral IAP repeat-containing protein 5

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human survivin(121-142aa KKEFEETAKKVRRAIEQLAAMD).

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Références pour anticorps anti-Survivin (ABIN3043195)

Gu, Ren, Wang, Qu, Zhang: "Expression of livin, survivin and caspase-3 in prostatic cancer and their clinical significance." dans: International journal of clinical and experimental pathology, Vol. 8, Issue 11, pp. 14034-9, (2016) (PubMed).

Zhang, Wang, Yang, Pan, Li, Yuan: "Preclinical pharmacodynamic evaluation of antibiotic nitroxoline for anticancer drug repurposing." dans: Oncology letters, Vol. 11, Issue 5, pp. 3265-3272, (2016) (PubMed).

Li, Zhao, Lu, Li, Yang, Wu, Liu: "Notch-1 signaling promotes the malignant features of human breast cancer through NF-?B activation." dans: PLoS ONE, Vol. 9, Issue 4, pp. e95912, (2014) (PubMed).

Zhang, Lu, Hou, Hu, Wang: "The effects of STAT3 and Survivin silencing on the growth of human bladder carcinoma cells." dans: Tumour biology, Vol. 35, Issue 6, pp. 5401-7, (2014) (PubMed).

Chen, Xie, Zhao, Wang, Bai, Yin, Jiang, Xie, Jia, Huang et al.: "Ampelopsin induces apoptosis by regulating multiple c?Myc/S?phase kinase?associated protein 2/F?box and WD repeat?containing protein 7/histone deacetylase 2 pathways in human lung adenocarcinoma ..." dans: Molecular medicine reports, Vol. 11, Issue 1, pp. 105-12, (2014) (PubMed).

Hao, Huang, Liao, Zhu, Liu, Hao, Liu, Zhang, Feng, Ning, Li, Li: "The inhibition of resveratrol to human skin squamous cell carcinoma A431 xenografts in nude mice." dans: Fitoterapia, Vol. 86, pp. 84-91, (2013) (PubMed).

Li, Zhang, Fang, Yan, Zhao, Feng, Ma, Ye: "Aspirin overcomes Navitoclax-resistance in hepatocellular carcinoma cells through suppression of Mcl-1." dans: Biochemical and biophysical research communications, Vol. 434, Issue 4, pp. 809-14, (2013) (PubMed).

Cai, Liu, Zhao, Wan, Hu, Zhou, Chen: "Expressions of survivin and vascular endothelial growth factor in a Murine model of proliferative retinopathy." dans: International journal of ophthalmology, Vol. 5, Issue 3, pp. 293-6, (2012) (PubMed).

Shan, Zhang, Geng, Zhou, Chen, Nie, Guo, Li, Liu, Guo, Wei, Chen: "Expression of survivin and human telomerase reverse transcriptase in extramammary Paget's disease." dans: Journal of cutaneous pathology, Vol. 37, Issue 6, pp. 635-40, (2010) (PubMed).

Détails sur Survivin

Antigène: Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))

Autre désignation: BIRC5 (BIRC5 Produits)

Synonymes: anticorps AP14, anticorps API4, anticorps EPR-1, anticorps AAC-11, anticorps Api4, anticorps TIAP, anticorps survivin40, anticorps bir5a, anticorps survivin, anticorps BIR1, anticorps Su2, anticorps XBIR1, anticorps XSurvivin1, anticorps Xsvv1, anticorps api4, anticorps bir1-A, anticorps epr-1, anticorps svv1, anticorps xSurvivin, anticorps xsurv, anticorps Su1, anticorps birc5.2, anticorps svv2, anticorps xSurvivin2, anticorps bir5b, anticorps SIX, anticorps birc5.2-a, anticorps birc5.2-b, anticorps baculoviral IAP repeat containing 5, anticorps baculoviral IAP repeat-containing 5, anticorps baculoviral IAP repeat containing 5a, anticorps baculoviral IAP repeat-containing 5, gene 1 L homeolog, anticorps baculoviral IAP repeat containing 5 L homeolog, anticorps baculoviral IAP repeat containing 5b, anticorps baculoviral IAP repeat containing 5 S homeolog, anticorps BIRC5, anticorps Birc5, anticorps birc5a, anticorps birc5.1.L, anticorps birc5.2.L, anticorps birc5b, anticorps birc5.2.S

Sujet: Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene. Survivin is a member of the inhibitor of apoptosis(IAP) family. The survivin gene contains 4 exons. The survivin gene is mapped to chromosome 17q25 by pulsed field gel electrophoresis and single- and 2-color FISH. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. The survivin protein is expressed highly in most human tumours and fetal tissue, but is completely absent in terminally differentiated cells.

Synonyms: API4 antibody|Apoptosis Inhibitor 4 antibody|Apoptosis inhibitor survivin antibody|Apoptosis inhibitor4 antibody|Baculoviral IAP repeat containing 5 antibody|Baculoviral IAP repeat containing protein 5 antibody|Baculoviral IAP repeat-containing protein 5 antibody|BIRC 5 antibody|BIRC5 antibody|EPR 1 antibody|IAP4 antibody|Survivin variant 3 alpha antibody|SVV antibody|TIAP antibody

UniProt: O15392

Pathways: Apoptose, Cycle Cellulaire, Nuclear Hormone Receptor Binding