DDR1 anticorps (C-Term)

N° du produit ABIN3044099

Détail du produit anti-DDR1 anticorps

Antigène: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Épitope: AA 898-913, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDR1 est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit IgG polyclonal antibody for Epithelial discoidin domain-containing receptor 1(DDR1) detection. Tested with WB in Human,Rat.

Séquence: FSQLHRFLAE DALNTV

Réactivité croisée (Details): Predicted Cross Reactivity: rat
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Attributs du produit: Rabbit IgG polyclonal antibody for Epithelial discoidin domain-containing receptor 1(DDR1) detection. Tested with WB in Human,Rat.
Gene Name: discoidin domain receptor tyrosine kinase 1
Protein Name: Epithelial discoidin domain-containing receptor 1

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human MCK10(898-913aa FSQLHRFLAEDALNTV), different from the related rat sequence by one amino acid, and from the related mouse sequence by two amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Predicted Species: Rat, The detection limit for DDR1 is approximately 0.5 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur DDR1

Antigène: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Autre désignation: DDR1 (DDR1 Produits)

Synonymes: anticorps CG11573, anticorps CG13984, anticorps CG13985, anticorps CG33531, anticorps CG9488, anticorps CG9490, anticorps CT33540, anticorps DDR, anticorps Dmel\\CG33531, anticorps Dmel_CG13984, anticorps 6030432F18, anticorps AI323681, anticorps CD167a, anticorps Cak, anticorps Nep, anticorps PTK3A, anticorps CAK, anticorps CD167, anticorps EDDR1, anticorps HGK2, anticorps MCK10, anticorps NEP, anticorps NTRK4, anticorps PTK3, anticorps RTK6, anticorps TRKE, anticorps Drd1, anticorps PTK3D, anticorps Discoidin domain receptor, anticorps discoidin domain receptor family, member 1, anticorps discoidin domain receptor tyrosine kinase 1, anticorps Ddr, anticorps Ddr1, anticorps DDR1

Sujet: DDR1(Discoidin domain receptor family, member 1) also known as NEP, EDDR1, NTRK4, TRKE, DDR, CAK or RTK6, is a human gene. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen.This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain.The DDR1 gene is mapped on 6p21.33. The fibrillar collagens and immobilized collagen activated DDR1 receptor phosphorylation after prolonged treatment. Bhatt et al.(2000) showed that Ddr1 was highly expressed in the cerebellum of developing and adult mouse brain, and that both Ddr1 and collagen IV were highly expressed in the pial layer of the cerebellar cortex. Cocultures of collagen I- and IV-expressing mouse pial cells with Ddr1-expressing granule cells resulted in granule cell neurite extension. Inhibition of collagen-Ddr1signaling reduced granule cell neurite elongation.

Synonyms: CAK antibody|CD 167 antibody|CD167 antibody|CD167 antigen-like family member A antibody|CD167a antibody|Cell adhesion kinase antibody|DDR 1 antibody|DDR antibody|DDR1 antibody|DDR1_HUMAN antibody|Discoidin domain receptor antibody|Discoidin domain receptor tyrosine kinase 1 antibody|Discoidin receptor tyrosine kinase antibody|Discoidin receptor tyrosine kinase isoform a antibody|EDDR 1 antibody|EDDR1 antibody|Epithelial discoidin domain receptor 1 antibody|Epithelial discoidin domain-containing receptor 1 antibody|Epithelial specific receptor kinase antibody|HGK2 antibody|Mammarian carcinoma kinase 10 antibody|Mammary carcinoma kinase 10 antibody|MCK-10 antibody|MCK10 antibody|NEP antibody|Neuroepithelial tyrosine kinase antibody|Neurotrophic tyrosine kinase receptor type 4 antibody|NTRK 4 antibody|NTRK4 antibody|OTTHUMP00000029343 antibody|OTTHUMP00000029344 antibody|OTTHUMP00000029345 antibody|OTTHUMP00000029346 antibody|OTTHUMP00000029347 antibody|OTTHUMP00000164863 antibody|OTTHUMP00000164867 antibody|OTTHUMP00000222080 antibody|Protein-tyrosine kinase 3A antibody|Protein-tyrosine kinase RTK-6 antibody|PTK 3 antibody|PTK 3A protein tyrosine kinase 3A antibody|PTK3 antibody|PTK3A antibody|Receptor tyrosine kinase NEP antibody|RTK 6 antibody|RTK6 antibody|TRK E antibody|TRKE antibody|Tyrosine kinase DDR antibody|Tyrosine kinase receptor E antibody|Tyrosine-protein kinase CAK antibody

UniProt: Q08345

Pathways: Signalisation RTK, Smooth Muscle Cell Migration