Presenilin 2 anticorps (N-Term)

N° du produit ABIN3044383

Cet anticorps Lapin Polyclonal détecte spécifiquement Presenilin 2 dans WB et IHC. Il présente une réactivité envers Humain, Rat et Souris.

Aperçu rapide pour Presenilin 2 anticorps (N-Term) (ABIN3044383)

Antigène: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Presenilin 2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Presenilin 2 anticorps

Épitope: AA 39-51, N-Term

Fonction: Anti-Presenilin 2/PSEN2 Antibody Picoband®

Séquence: EDGENTAQWR SQE

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-Presenilin 2/PSEN2 Antibody (ABIN3044383). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human Presenilin 2, different from the related mouse and rat sequences by two amino acids.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat, Mouse
Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse
1. Levy-Lahad E, Wijsman EM, Nemens E, Anderson L, Goddard KA, Weber JL, Bird TD, Schellenberg GD (September 1995). "A familial Alzheimer's disease locus on chromosome 1". 2. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy".

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Presenilin 2

Antigène: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Autre désignation: PSEN2

Sujet:

Synonyms: Presenilin-2,PS-2,3.4.23.-,AD3LP,AD5,E5-1,STM-2,Presenilin-2 NTF subunit,Presenilin-2 CTF subunit,PSEN2,AD4, PS2, PSNL2, STM2,

Tissue Specificity: Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney. .

Background: Presenilin-2 is a protein that in humans is encoded by the PSEN2 gene. Kovacs et al. (1996) demonstrated that the expression patterns of PS1 and PS2 in the brain are extremely similar to each other and that messages for both are primarily detectable in neuronal populations. Immunochemical analyses indicated that PS1 and PS2 are similar in size and localize to similar intracellular compartments (endoplasmic reticulum and Golgi complex). Li et al. (1997) demonstrated that wildtype PS1 and PS2 are localized to the nuclear membrane, its associated interphase kinetochores, and the centrosomes.In melanocytic cells PSEN2 gene expression may be regulated by MITF.

Sequence Similarities: Belongs to the peptidase A22A family.

Poids moléculaire: 60 kDa

UniProt: P49810

Pathways: Signalisation Notch, EGFR Signaling Pathway, Neurotrophin Signaling Pathway