GZMA anticorps (Middle Region)

N° du produit ABIN3044452

Détail du produit anti-GZMA anticorps

Antigène: GZMA (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA))

Épitope: AA 175-190, Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GZMA est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for Granzyme A(GZMA) detection. Tested with WB, IHC-P in Human.

Séquence: DRKVCNDRNH YNFNPV

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Granzyme A(GZMA) detection. Tested with WB, IHC-P in Human.
Gene Name: granzyme A(granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
Protein Name: Granzyme A

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of human Granzyme A(175-190aa DRKVCNDRNHYNFNPV).

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur GZMA

Antigène: GZMA (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA))

Autre désignation: GZMA (GZMA Produits)

Synonymes: anticorps gzmA, anticorps GZMA, anticorps AW494114, anticorps Ctla-3, anticorps Ctla3, anticorps Hf, anticorps SE1, anticorps TSP-1, anticorps TSP1, anticorps CTLA3, anticorps HFSP, anticorps granzyme A, anticorps Granzyme A, anticorps granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3), anticorps gzmA, anticorps GZMA, anticorps graa, anticorps Gzma

Sujet: Granzyme A is a protein that in humans is encoded by the GZMA gene. Cytolytic T lymphocytes(CTL) and natural killer(NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are though to protect their host by lysing cells bearing on their surface "nonself" antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. GZMA induces caspase-independent apoptosis in a characteristic manner, except it causes a distinctive form of DNA damage: single-stranded DNA nicking. A target of GZMA is the SET complex, including HMGB2 and ANP32A .

Synonyms: CTL tryptase antibody|CTLA3 antibody|Cytolytic t cell and natural killer cell specific trypsin like serine protease antibody|Cytotoxic T lymphocyte associated serine esterase 3 antibody|Cytotoxic T lymphocyte proteinase 1 antibody|Cytotoxic T-lymphocyte proteinase 1 antibody|Fragmentin 1 antibody|Fragmentin-1 antibody|GRAA_HUMAN antibody|Granzyme 1 cytotoxic T lymphocyte associated serine esterase 3 antibody|Granzyme A(Cytotoxic T lymphocyte associated serine esterase 3, Hanukah factor serine protease) antibody|Granzyme A(granzyme 1, cytotoxic T lymphocyte associated serine esterase 3) antibody|Granzyme A antibody|Granzyme A precursor antibody|Granzyme-1 antibody|GZMA antibody|H factor antibody|Hanukah factor serine protease antibody|Hanukkah factor antibody|HF antibody|HFSP antibody|TSP1 antibody

UniProt: P12544

Pathways: Apoptose