CHEK1 anticorps

N° du produit ABIN306587

L’anticorps Mouton Polyclonal anti-CHEK1 a été validé pour . Il convient pour détecter CHEK1 dans des échantillons de Humain, Souris, Rat et Singe.

Aperçu rapide pour CHEK1 anticorps (ABIN306587)

Antigène: CHEK1 (Checkpoint Kinase 1 (CHEK1))

Reactivité: Humain, Souris, Rat, Singe

Hôte: Mouton

Clonalité: Polyclonal

Conjugué: Cet anticorp CHEK1 est non-conjugé

Application: Veuillez nous consulter SVP

Détail du produit anti-CHEK1 anticorps

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Détails sur CHEK1

Antigène: CHEK1 (Checkpoint Kinase 1 (CHEK1))

Autre désignation: chk 1 kinase

Sujet: The immunogen for anti-human chk-1 was a GST fusion protein corresponding to amino acid sequence 1-474 and having a molecular weight of 54 kD. One mechanism by which checkpoints maintain the fidelity of cell cycle events is through blocking mitosis in response to unreplicated or damaged DNA. In most species this occurs through inhibiting activation of the cyclic-dependent kinase cdc2, which regulates entry in to mitosis. Chk1, a kinase involved in the DNA damage checkpoint response can phosphorylate Cdc25C an activator of cdc2. It is hypothesized that chk 1 induces serine 216 phosphorylation of Cdc 25C and subsequent binding negatively regulated Cdc25C, thus preventing it from activating cdc2. Synonyms: sheep anti human chk 1 kinase, checkpoint kinase 1.

UniProt: O14757

Pathways: Signalisation p53, Apoptose, Cycle Cellulaire, Réparation de l'ADN