CHEK1 anticorps

N° du produit ABIN306587

L’anticorps anti-CHEK1 Polyclonal Mouton est utilisé pour la détection de CHEK1 dans des échantillons de Humain, Souris, Rat et Singe. Il a été validé pour WB et IP.

Aperçu rapide pour CHEK1 anticorps (ABIN306587)

Antigène: CHEK1 (Checkpoint Kinase 1 (CHEK1))

Reactivité: Humain, Souris, Rat, Singe

Hôte: Mouton

Clonalité: Polyclonal

Conjugué: Cet anticorp CHEK1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Détail du produit anti-CHEK1 anticorps

Fonction: Sheep anti Human chk 1 kinase

Attributs du produit: One mechanism by which checkpoints maintain the fidelity of cell cycle events is through blocking mitosis in response to unreplicated or damaged DNA. In most species this occurs through inhibiting activation of the cyclic-dependent kinase cdc2, which regulates entry in to mitosis. Chk1, a kinase involved in the DNA damage checkpoint response can phosphorylate Cdc25C an activator of cdc2. It is hypothesized that chk 1 induces serine 216 phosphorylation of Cdc 25C and subsequent binding negatively regulated Cdc25C, thus preventing it from activating cdc2.

Purification: Ammonium Sulfate Precipitation

Isotype: IgG

Information d'application

Indications d'application: Western Blot at 1 - 10 μg/mL.

Restrictions: For Research Use only

Stockage

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détails sur CHEK1

Antigène: CHEK1 (Checkpoint Kinase 1 (CHEK1))

Autre désignation: chk 1 kinase

Sujet: Sheep anti human chk 1 kinase, checkpoint kinase 1

UniProt: O14757

Pathways: Signalisation p53, Apoptose, Cycle Cellulaire, Réparation de l'ADN