CACNA1C anticorps

N° du produit ABIN306889

Détail du produit anti-CACNA1C anticorps

Antigène: CACNA1C (Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CACNA1C est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain

Attributs du produit: Neuronal voltage-gated calcium channel gamma-3 subunit, Transmembrane AMPAR regulatory protein gamma-3, Voltage-dependent calcium channel gamma-3 subunit,Voltage-dependent calcium channels (VDCCs) are large (>400 kDa) heteromers which contain, minimally, three core subunits 1, 2/ , in a 1:1:1 stoichiometry1. Expression of VDCC gene products in Xenopus oocytes, or transfected cells shows that the 1 subunits contain the ion channel pore while the auxiliary 2/ and subunits confer optimal cell surface expression and channel kinetics1. Until recently, the only exception to the above paradigm was the skeletal muscle VDCC, which, in addition to the 1, 2/ , core motif, also has an additional tightly associated integral membrane glycoprotein subunit termed 1. Upon co-expression with the 1.1, 2/ 1, 1a subunits of the skeletal muscle VDCC, subunits alter the peak currents, and the kinetics of channel activation and inactivation with the overall effect being a normalisation of currents to those resembling the endogenous channel2. Together, these results suggest that subunits modulate skeletal muscle VDCCs by stabilising their conformation. The 3 subunit is specifically localized in the brain, with the 2 and 4 subunits. It shares >60 % sequence homology with the 2 and 4 subunits and ~25 % sequence homology with the 1 and 5 subunits.

Purification: Ammonium Sulfate Precipitation

Immunogène: Synthetic peptide derived from the rat calcium channel gamma3 subunit conjugated to KLH

Isotype: IgG

Information d'application

Indications d'application: This antibody can be used for Western blotting at 5-10 μg/mL. Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Stockage

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détails sur CACNA1C

Antigène: CACNA1C (Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C))

Autre désignation: Calcium Channel (CACNA1C Produits)

Synonymes: anticorps CACH2, anticorps CACN2, anticorps CACNL1A1, anticorps CCHL1A1, anticorps CaV1.2, anticorps LQT8, anticorps TS, anticorps Cav1.2, anticorps Cchl1a1, anticorps MBC, anticorps MELC-CC, anticorps RATIVS302, anticorps isl, anticorps C-LTCC, anticorps CHCACHA1C, anticorps ICA, anticorps cav1.2, anticorps ca(v)1.2, anticorps CAV1.2, anticorps BCR, anticorps rbc, anticorps calcium voltage-gated channel subunit alpha1 C, anticorps calcium channel, voltage-dependent, L type, alpha 1C subunit, anticorps voltage-dependent L-type calcium channel subunit alpha-1C, anticorps calcium channel, voltage-dependent, L type, alpha 1C subunit S homeolog, anticorps Red blood cell count, anticorps RNA, 7SL, cytoplasmic 263, pseudogene, anticorps CACNA1C, anticorps Cacna1c, anticorps cacna1c, anticorps LOC100442085, anticorps cacna1c.S, anticorps RBC, anticorps RN7SL263P

UniProt: O60359

Pathways: Hormone Transport, Carbohydrate Homeostasis