PPAP2B anticorps

N° du produit ABIN306894

Détail du produit anti-PPAP2B anticorps

Antigène: PPAP2B (Phosphatidic Acid Phosphatase Type 2B (PPAP2B))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPAP2B est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain

Attributs du produit: Lipid phosphate phosphohydrolase 3, EC 3.1.3.4 Phosphatidic acid phosphatase 2b, PAP2-beta ,PAP-2b, PAP2b, Phosphatidate phosphohydrolase type 2b, Vascular endothelial growth factor and type I collagen-inducible protein, VCIP,Phosphatidic acid phosphatase type 2 (PAP2) was originally identified as a plasma membrane enzyme that catalyses the dephosphorylation of the putative second messenger, phosphatidic acid (PA) to diacylglycerol (DG) [1]. Subsequently, multiple isoforms of PAP2 were cloned [2-5]. It was found that these enzymes dephosphorylate a number of lipid phosphates in vitro other than PA, including the potent bioactive lipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Therefore, they have been renamed lipid phosphate phosphatases (LPPs). Currently, there are four members of this family called LPP1, LPP1a, LPP2 and LPP3 [6]. S1P [7] and LPA [8] regulate the proliferation, differentiation, apoptosis and migration of cells by binding to a family of G protein-coupled receptors. Thus, EDG1/S1P1, EDG3/S1P3, EDG5/S1P2/AGR16/H218, EDG6/S1P4 and EDG8/S1P5/nrg-1 are high affinity S1P receptors [7] whereas EDG2/LPA1, EDG4/LPA2 and EDG7/LPA3 have high affinity for LPA [8]. Recently, the over-expression of LPP1 was shown to limit LPA-stimulated signalling in Rat2 fibroblasts [9] and LPA-stimulated DNA synthesis in HEK 293 cells [10]. Similarly, over-expression of LPP1, LPP1a and LPP2 attenuate S1P-signalling to the p42/p44 mitogen activated protein kinase cascade [11].

Purification: Ammonium Sulfate Precipitation

Immunogène: Rabbits were immunized with a unique peptide derived from the human lysophospholipid phosphatase 3 protein.

Isotype: IgG

Information d'application

Indications d'application: This antibody can be used for Western blotting (10-15 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Stockage

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détails sur PPAP2B

Antigène: PPAP2B (Phosphatidic Acid Phosphatase Type 2B (PPAP2B))

Autre désignation: Lyosphospholipid Phosphatase (LPP) 3 (PPAP2B Produits)

Synonymes: anticorps Dri42, anticorps LPP3, anticorps PAP2B, anticorps VCIP, anticorps 1110003O22Rik, anticorps 2610002D05Rik, anticorps AV025606, anticorps D4Bwg0538e, anticorps D4Bwg1535e, anticorps Lpp3, anticorps Ppab2b, anticorps dri42, anticorps lpp3, anticorps pap2b, anticorps ppap2bb, anticorps vcip, anticorps ppap2b, anticorps ppap2ba, anticorps PPAP2B, anticorps si:dkey-19f4.1, anticorps phospholipid phosphatase 3, anticorps phospholipid phosphatase 3 L homeolog, anticorps phospholipid phosphatase 3 S homeolog, anticorps PLPP3, anticorps Plpp3, anticorps plpp3.L, anticorps plpp3.S, anticorps plpp3