Sema4a anticorps

N° du produit ABIN308219

Détail du produit anti-Sema4a anticorps

Antigène: Sema4a (Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Sema4a est non-conjugé

Application: ELISA, Immunoprecipitation (IP), Flow Cytometry (FACS)

Purification: Protein G purified

Immunogène: Peptide of mouse Sema4A extracellular domain. Raised in Sema4A deficient mouse. Myeloma: P3U1

Clone: HIAT-2

Isotype: IgG1 kappa

Information d'application

Indications d'application: ELISA 1.0-10 ug/mL, FACS 50 ng/mL, IP 5.0 ug/mL

Restrictions: For Research Use only

Stockage

Concentration: 250ug/ml

Buffer: PBS [containing 2 % Block Ace as a stabilizer, 0.1 %Proclin as a bacteriostat]

Agent conservateur: ProClin

Détails sur Sema4a

Antigène: Sema4a (Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a))

Autre désignation: Semaphorin 4A (Sema4A) (Sema4a Produits)

Synonymes: anticorps SEMA4A, anticorps CORD10, anticorps RP35, anticorps SEMAB, anticorps SEMB, anticorps AI132332, anticorps SemB, anticorps Semab, anticorps semaphorin 4A, anticorps sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A, anticorps SEMA4A, anticorps sema4a, anticorps Sema4a

Sujet: Semaphorins are a family of phylogenetically conserved soluble and transmembrane proteins. Semaphorins were originally identified as axon guidance factors during neuronal development. Semaphorins are now known to be widely expressed mediators that play significant roles in immune responses and organ morphogenesis. The class IV semaphoring subfamily member, Sema4A was identified originally as a semaphorin expressed in developing embryos, and Sema4A transcript levels increase gradually throughout embryonic development. Sema4A is expressed in the brain, lung, kidney, testis, and spleen of adults. In the immune system, Sema4A is preferentially expressed by bone marrow-derived and splenic dendritic cells (DCs), but not by resting T cells. Expression of Sema4A also becomes detectable on the cell surface of T cells following activation. Sema4A regulates T-cell-mediated immune responses by interacting with its receptor Tim-2, which is expressed on TH2 cells as a negative regulator. Sema4A expression is specifically induced on the cell surface of TH1 cells during helper T-cell differentiation. T-cell derived Sema4A is necessary for regulating T-cell differentiation. Sema4A expressed on endothelial cells, directly binds to Plexin-D1 and negatively regulates VEGF-dependent vascular formation. It is also suggested that Sema4A is critically involved in the development of myocarditis and dilated cardiomyopathy.

ID gène: 20351