Endothelin-1 Receptor anticorps

N° du produit ABIN317635

Détail du produit anti-Endothelin-1 Receptor anticorps

Antigène: Endothelin-1 Receptor (EDNRA) (Endothelin Receptor Type A (EDNRA))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Endothelin-1 Receptor est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificité: This antibody detects endogenous levels of Endothelin Receptor A (ETAR) protein.(region surrounding asn427)

Purification: Affinity Chromatography using epitope-specific immunogen.

Information d'application

Indications d'application: ELISA: 1/5000-1/10000. Western Blot: 1/500-1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS, pH ~7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Endothelin-1 Receptor

Antigène: Endothelin-1 Receptor (EDNRA) (Endothelin Receptor Type A (EDNRA))

Autre désignation: Endothelin A Receptor (EDNRA Produits)

Synonymes: anticorps ET-A, anticorps ETA, anticorps ETA-R, anticorps ETAR, anticorps ETRA, anticorps hET-AR, anticorps ET-AR, anticorps Endor, anticorps Eta, anticorps RGD1559432, anticorps ETa, anticorps Gpcr10, anticorps ednr-a, anticorps ednra, anticorps wu:fb75g12, anticorps ednraa, anticorps eta, anticorps etar, anticorps etra, anticorps zgc:85942, anticorps endothelin receptor type A, anticorps endothelin receptor type Aa, anticorps endothelin receptor type A L homeolog, anticorps endothelin receptor type Ab, anticorps EDNRA, anticorps Ednra, anticorps ednraa, anticorps ednra.L, anticorps ednra, anticorps ednrab

Sujet: Endothelin receptor A (ETAR), also known as EDNRA, ET1 receptor, ETA, EDN1 and ET-AR, is a member of the guanine-binding regulatory protein-coupled receptor family. ETAR binds endothelins and has the highest affinity for its ligand, ET1, as compared to the ETBR receptor. Both ET receptors, ETAR and ETBR, are activated by ET1, which results in inhibition of active lens sodiumpotassium transport. Activation of the ET receptors also causes an increase in cytoplasmic calcium concentration in cultured lens epithelial cells. In addition, ETAR induces arachidonic acid accumulation. ETAR has seven hydrophobic transmembrane domains and is expressed in aorta, lung, atrium, kidney, placenta and prostate. Specifically, placental vascular smooth muscle cells (PVSMCs) exclusively express ETAR.Synonyms: EDNRA, ET-A, ETA, ETA-R, ETRA, Endothelin-1 receptor, endothelin receptor type A, hET-AR

Poids moléculaire: approx. 50 kDa

ID gène: 1909

NCBI Accession: NP_001159527

UniProt: P25101

Pathways: cAMP Metabolic Process