Neurofibromin 1 anticorps

N° du produit ABIN317682

Détail du produit anti-Neurofibromin 1 anticorps

Antigène: Neurofibromin 1 (NF1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Neurofibromin 1 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody detects endogenous levels of Neurofibromin protein.(region surrounding Arg1575)

Purification: Affinity Chromatography using epitope-specific immunogen.

Information d'application

Indications d'application: ELISA: 1/20000-1/40000. Western Blot: 1/500-1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Neurofibromin 1

Antigène: Neurofibromin 1 (NF1)

Autre désignation: Neurofibromin (NF1 Produits)

Synonymes: anticorps NFNS, anticorps VRNF, anticorps WSS, anticorps CG8318, anticorps Dmel\\CG8318, anticorps NF-1, anticorps NF1, anticorps Nf-1, anticorps dNF1, anticorps nf1, anticorps fe06d03, anticorps hm:zehn0874, anticorps wu:fe06d03, anticorps zehn0874, anticorps AW494271, anticorps E030030H24Rik, anticorps neurofibromin 1, anticorps Neurofibromin 1, anticorps neurofibromin 1a, anticorps neurofibromin, anticorps putative neurofibromin, anticorps NF1, anticorps Nf1, anticorps nf1a, anticorps LOC593418, anticorps LOC5570549, anticorps CpipJ_CPIJ011774, anticorps Smp_148460

Sujet: Neurofibromatosis type 1 (NF1), or von Reckinghausen neurofibromatosis, is one of the most common autosomal dominant disorders in humans. Early linkage analysis mapped the NF1 gene to chromosome 17. The predicted NF1 transcript encodes a 2818 amino acid protein designated NF1GRP. By sequence analysis, similarity has been demonstrated within a small region of NF1GRP and members of the Ras GAP gene family. Functionally, NF1GRP was shown by biochemical analysis involving RAS-GAP hydrolysis and functional complementation in yeast to further resemble GAP protein. The NF1 protein is expressed at relatively constant levels in a broad range of cell lines and tissues including brain, lung, liver, kidney, spleen, muscle and colon. Although little is known regarding the function of NF1GRP, the homology with the catalytic domain of proteins with GTPase activity suggests that the NF1GRP may also interact in vivo with Ras proteins.Synonyms: NF-1, NF1

Poids moléculaire: approx. 319 kDa

ID gène: 4763

NCBI Accession: NP_000258

UniProt: P21359

Pathways: cAMP Metabolic Process, Regulation of long-term Neuronal Synaptic Plasticity