SLC16A3
Reactivité: Humain
Hôte: Lapin
Polyclonal
FITC
Indications d'application
ELISA: 1/40000-1/60000. Western Blot: 1/500-1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Concentration
1.0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH ~7.2 with 0.05 % Sodium Azide as preservative
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Antigène
SLC16A3
(Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 3 (SLC16A3))
anticorps MCT 3, anticorps MCT 4, anticorps MCT-3, anticorps MCT-4, anticorps MCT3, anticorps MCT4, anticorps mct, anticorps slc16a3b, anticorps Mct3, anticorps Mct4, anticorps MCT4b, anticorps wu:fd20b02, anticorps wu:fi38f12, anticorps zgc:55905, anticorps solute carrier family 16 member 3, anticorps solute carrier family 16 member 3 L homeolog, anticorps solute carrier family 16 (monocarboxylic acid transporters), member 3, anticorps solute carrier family 16 (monocarboxylate transporter), member 3, anticorps SLC16A3, anticorps slc16a3.L, anticorps Slc16a3, anticorps slc16a3
Sujet
Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs),which function as proton symports and are stereoselective for L-lactate.The MCT family consists of at least eight members, MCT1-8, which contain between 10-12 transmembrane-helical (TM) domains, with the amino and carboxy termini located in the cytoplasm. MCT1 is widely expressed and is the major form of MCTs in tumor cells and erythrocytes. MCT2 is highly expressed in liver and testis, while MCT3 and MCT4 are predominantly expressed in skeletal muscle.Synonyms: MCT 3, MCT 4, MCT3, MCT4, Monocarboxylate transporter 3, Monocarboxylate transporter 4, Solute carrier family 16 member 3