SH2B3 anticorps (N-Term)

N° du produit ABIN318699

Détail du produit anti-SH2B3 anticorps

Antigène: SH2B3 (SH2B Adaptor Protein 3 (SH2B3))

Épitope: N-Term

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp SH2B3 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody recognises an epitope within the N-terminal region (NT) of lymphocyte adaptor protein (LNK).

Purification: Antisera to LNK (NT) were raised by repeated immunisation of Goat with highly purified antigen. Purified IgG prepared by affinity chromatography.

Immunogène: Peptide sequence NGPALQPSSPC from LNK amino-terminus.

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 0.3 - 1.0g/mL, detects a band of approximately 70 kDa in human MOLT4 celllysates. (Predicted Mwt.63.0 kDa)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5mg/mL

Buffer: TRIS buffered saline containing 0.02 % Sodium Azide and 0.5 % Bovine Serum Albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur SH2B3

Antigène: SH2B3 (SH2B Adaptor Protein 3 (SH2B3))

Autre désignation: SH2B3 (SH2B3 Produits)

Synonymes: anticorps LNK, anticorps IDDM20, anticorps AI429800, anticorps Lnk, anticorps SH2B adaptor protein 3, anticorps SH2B3, anticorps Sh2b3

Sujet: LNK is an SH2-containing adaptor protein, which regulates cytokine receptor-mediated and growth factor pathways, and plays an essential role in B cell lymphopoiesis. LNK mRNA is preferentially expressed in lymph node and spleen lymphocytes and the expression of LNK in vascular endothelial cells (ECs), increases in response to TNFalpha. The role of LNK as a negative regulator, includes the down regulation of the pro-inflammatory molecules VCAM-1 and E-selectin induced by TNFalpha, modulation of P13-kinase and MAPK ERK1/2 activity, and negative regulation of Thrombopoietin-mediated cell proliferation and endomitosis in hematopoietic cell lines.Synonyms: LNK, Lymphocyte adapter protein, Lymphocyte-specific adapter protein Lnk, SH2B adapter protein 3, SH2B3, Signal transduction protein Lnk

ID gène: 10019

NCBI Accession: NP_005466

UniProt: Q9UQQ2