p53 anticorps (acLys382)

N° du produit ABIN3201008

Cet anticorps anti-p53 est un anticorps Souris Monoclonal détectant p53 dans WB et IF. Adapté pour Humain. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour p53 anticorps (acLys382) (ABIN3201008)

Antigène: p53 (TP53) (Tumor Protein P53 (TP53))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp p53 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 2B7E4

Détail du produit anti-p53 anticorps

Épitope: acLys382

Specificité: Reacts with human p53 acetylated at Lys382.

Réactivité croisée (Details): Not tested for other species

Purification: Purified

Stérilité: Sterile filtered

Immunogène: Synthetic peptide containing acLys382 of human p53

Isotype: IgG1 kappa

Information d'application

Indications d'application: 1) Wester blotting: ~1 g/mL
2) Immunoflurescence staining: 1/1,000 dilution
Other applications have not been tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS ( pH 7.4), 50 % glycerol

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Upon arrival centrifuge briefly and store at -20 C.

Références pour anticorps anti-p53 (ABIN3201008)

Bode, Dong: "Post-translational modification of p53 in tumorigenesis." dans: Nature reviews. Cancer, Vol. 4, Issue 10, pp. 793-805, (2004) (PubMed).

Détails sur p53

Antigène: p53 (TP53) (Tumor Protein P53 (TP53))

Autre désignation: p53

Sujet: P53 mutants are found in more than half of human cancers and are considered as the most important human cancer related gene. p53 is detected at 53kD position by electrophoresis and is composed of 393 amino acids. In the unstressed normal cells, the p53 level is low and it is inactive. However, with stress, especially with DNA damage, it is activated to promote arrest of cell cycle and repair of DNA damage, or induction of apoptosis. The functions and stability of p53 are regulated by phosphorylation of serine and threonine, and acetylation of lysine at various sites in the molecule. Acetylation of lysine 382 (acetyl-K382) of p53 occurs after DNA damage and is catalyzed by the p300/CBP acetyltransferase, which stabilizes p53 proten.

UniProt: P04637

Pathways: Signalisation p53, Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, L'effet Warburg