Choline Acetyltransferase anticorps

N° du produit ABIN349982

Détail du produit anti-Choline Acetyltransferase anticorps

Antigène: Choline Acetyltransferase (CHAT) (Choline O-Acetyltransferase (CHAT))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Choline Acetyltransferase est non-conjugé

Application: Immunohistochemistry (IHC)

Specificité: Specific for ChAT.

Réactivité croisée: Humain, Souris, Rat

Réactivité croisée (Details): Other species not yet tested.

Purification: IgG

Immunogène: A synthetic peptide from mouse ChAT conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and human.

Isotype: IgG

Information d'application

Indications d'application: IHC. A working concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.

Conseil sur la manipulation: Avoid freeze and thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Date de péremption: 12 months

Détails sur Choline Acetyltransferase

Antigène: Choline Acetyltransferase (CHAT) (Choline O-Acetyltransferase (CHAT))

Autre désignation: ChAT (CHAT Produits)

Synonymes: anticorps CHOACTASE, anticorps CMS1A, anticorps CMS1A2, anticorps ChoAcTase, anticorps B230380D24Rik, anticorps choline O-acetyltransferase, anticorps choline O-acetyltransferase a, anticorps choline acetyltransferase, anticorps carnitine O-acetyltransferase, anticorps CHAT, anticorps chata, anticorps Chat, anticorps PGTG_00551, anticorps LOC100533322

Sujet: Cholinergic systems are implicated in numerous neurologic functions. Alteration in some cholinergic neurons may account for the disturbances of Alzheimer disease. The protein encoded by this gene synthesizes the neurotransmitter acetylcholine. Alternative splice variants have been found that contain alternative 5' untranslated exons. Three of the four described splice variants encode identical 69 kDa proteins while one variant encodes both the 69 kDa and a larger 82 kDa protein. Choline acetylase catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. CATALYTIC ACTIVITY: Acetyl-CoA + choline = CoA + O-acetylcholine. Defects in CHAT are the cause of familial infantile myasthenia gravis 2 (FIMG2), also known as CMS-EA. FIMG2 patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement. Inheritance is autosomal recessive.,Neurotransmission,CHOACTase, choline acetylase, choline O-acetyltransferase, CMS1A, CMS1A2

UniProt: P28329

Pathways: Skeletal Muscle Fiber Development